ElectroPheX · Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-06-01 → 2024-07-31
- Финансиране от ЕС
- 246 669 €
- Участници
- 2
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Електрохимичното добавяне на халогени към феноли помага за създаването на сложни многозаместени ароматни съединения. Тези структури са важни за синтеза на нови лекарства и материали в науката.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.
Poly-substituted aromatics (PSAs) are of paramount importance in Organic Chemistry (synthesis intermediates), Medicinal Chemistry (pharmaceutical compounds) and material Science. The highly hindered nature of these compounds makes their synthesis a longstanding challenge for the synthetic community. Thus, the development of tools that will allow us to access them in a selective manner are of interest. ElectroPheX aims to develop synthetic methodologies that successfully access poly-substituted aromatics by first halogenate (X) Phenols under Electrochemical conditions.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
ElectroPheX aims to develop electrochemically-mediated methods for the site-selective halogenation of phenols. Electrochemistry will be the main feature of this project as it can be an efficient way to access and manipulate reactive intermediates. The project will span disciplines (interdisciplinarity) and aims to study electrochemistry’s ability to act as an enhancement tool for both selectivity and reactivity. Electrochemistry will help us to: (1) help us study the redox properties of catalysts, compounds, complexes and substrates (find redox potentials etc.); (2) to generate open-shell species; and, (3) to adjust the oxidation state of metals.WP1-ORTHO focuses on (1) the design and synthesis of a series of compounds that contain N-halogen bond and they are capable of facilitating the ortho-halogenation of phenols upon anodic oxidation, (2) the study of intermolecular interactions and how the electrochemical generation of the corresponding radical-cation of N-halogen bond will alter/enhance the strength of the former.WP2-META aims at the development of an electrochemically-mediated methodology for the meta-halogenation of phenols. Early transition metals (Mn, Co) will be used in order to facilitate the desired transformation. Electrochemistry will orchestrate the whole procedure giving access to adjacent oxidation states of metallic centers. WP3-PARA targets para-halogenation of phenols mediated by a novel catalyst that mimics a main feature of photosystem II leading to a proton-coupled electron transfer (PCET) protocol for the transformation. In WP4 the acquired knowledge will be translated to complex phenolic compounds in order to achieve a late-stage functionalization. SAR libraries, PET radiotracer, Also, the synthesis of highly site-selective halogenation of phenols can provide valuable intermediates for the preparation of poly-substituted arenes with a well-defined relationship between their substituent via cross-coupling reactions.
Оригинален текст от CORDIS (на английски).
Участници
- MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG · Muelheim An Der RuhrКоординаторГермания
- THE SCRIPPS RESEARCH INSTITUTE CORPORATION · LA JOLLAСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз