H2020Индивидуална стипендия2021–2023

OMEGA · Online Monitoring: Electrochemiluminescence based Gated Assay

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-01 → 2023-08-31
Финансиране от ЕС: 162 806 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Нови методи за откриване на замърсявания във вода и храна, като живак и пестициди, се тестват чрез специални наночастици и светлинни сигнали. Това помага за създаването на евтини и преносими устройства за бърз анализ на място.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Online Monitoring: Electrochemiluminescence based Gated Assay

To find new and better ways to detect and monitor contamination of water, food and the environment as early as possible directly at the site of impact is one of the most pressing tasks for researchers today. Early detection of and strategic monitoring to trace contamination of water is therefore crucial. This emphasizes the need for sensitive, robust, portable and affordable (especially for low-income countries) analysis tools that can report directly at site on the concentration of a target contaminant. Detecting contamination early means that these small, mobile analytical devices must indicate analytes at very low concentrations with reliable uncertainty and accuracy, to avoid false positives and foster acceptance of such tools by relevant user groups like public employees. In this project, attempts were made to address these problems by relying on the integration of gated delivery systems, magnetic beads, fluorescence spectroscopy and electrochemiluminescence (ECL) detection. ECL is a detection method that operates against a zero background while fluorescence spectroscopy provides highly sensitive detection. In addition, gated delivery systems exhibit inherent features of signal amplification. Silica nanoparticle based gated dye delivery systems were successfully developed for the detection of toxic heavy metal ions such as Hg2+ as well as organophosphate pesticide chlorpyrifos. These systems could detect the analytes at trace levels. A combination of these strategies with the versatile handling and miniaturization capabilities of microfluidics has the potential to yield user-friendly, affordable and robust analytical devices with unprecedented performance for the reliable quantification of analytes at ultra-trace levels directly on-site at the point- of-need.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

To find new and better ways to detect and monitor contamination of water, food and the environment as early as possible directly atthe site of impact is one of the most pressing tasks for researchers today. Early detection of and strategic monitoring to tracecontamination of water is therefore crucial. This emphasizes the need for sensitive, robust, portable and affordable (especially forlow-income countries) analysis tools that can report directly at site on the concentration of a target contaminant. Detectingcontamination early means that these small, mobile analytical devices have to indicate analytes at very low concentrations withreliable uncertainty and accuracy, to avoid false positives and foster acceptance of such tools by relevant user groups like publicemployees. In this project, I will address this need relying on the integration of microfluidics, gated delivery systems, magnetic beadsand electrochemiluminescence (ECL) detection. ECL is a detection method that operates against a zero background and gateddelivery systems exhibit inherent features of signal amplification. A combination of both strategies with the versatile handling andminiaturization capabilities of magnetic beads and microfluidics promises to yield user-friendly, affordable and robust analyticaldevices with unprecedented performance for the reliable quantification of analytes at ultra-trace levels (ppb and below) directly onsiteat the point-of-need. By matching my expertise in electrochemistry and microfluidics with the host’s expertise in gated deliverysystems, magnetic beads, luminescence spectroscopy and device integration, I have the unique opportunity to receive training invarious other disciplines, including metrology, that allow me to broaden my field of knowledge and to better shape the outline ofmy future career as a high-level (bio)analytical scientist.

Оригинален текст от CORDIS (на английски).

Участници

BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG · BerlinКоординаторГермания