T.I.M.E. · Temporal Impairment in Mapping Events: linguistic and non-linguistic time in aphasia
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2022-03-18 → 2025-03-17
- Финансиране от ЕС
- 245 732 €
- Участници
- 2
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Връзката между езика и възприемането на времето се анализира при хора с афазия – разстройство след инсулт, което затруднява комуникацията. Подоброто разбиране на тези когнитивни дефицити е важно, тъй като милиони хора в Европа живеят с последиците от инсулт.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Temporal Impairment in Mapping Events: linguistic and non-linguistic time in aphasia
“Time has a new meaning. It’s all elongated and transient. […] I’ve got no sense of time.” — My Beautiful Broken Brain (Robinson & Sodderland, 2014) These are the words of Lotje, a young stroke survivor, describing how her perception of time changed after brain injury. Her experience reflects a broader, underrecognized challenge among stroke survivors, especially those who develop aphasia—a language disorder often resulting from damage to the brain’s language regions. According to the 2025 World Stroke Organization Global Stroke Fact Sheet, stroke remains one of the most pressing global health challenges. Worldwide, nearly 94 million people are currently living with the effects of stroke, with over 11.9 million new strokes occurring annually. The American Speech-Language-Hearing association (ASHA) reports that roughly 25%–50% of all strokes result in aphasia. In Spain, and according to data from the Spanish Society of Neurology (SEN), more than 350.000 people suffer from aphasia, and around 25.000 new cases occur each year. Yet, based on the NAA 2022 survey on aphasia awareness in the USA, only 40% of people have heard of aphasia and can identify it as a language disorder, and 33.3% of the people who know what aphasia is either have aphasia or know someone who has it. The overall aim of the T.I.M.E. project was to advance the understanding of language comprehension abilities in stroke survivors with aphasia—a disorder that impairs a person’s ability to communicate. With stroke as a leading cause of disability in Europe, impacting millions, enhancing our comprehension of aphasia deficits through this research is pivotal. In particular, the T.I.M.E. project addressed a critical gap in our understanding of how stroke survivors process time—a fundamental cognitive function. This research is vital to society, as time perception is deeply intertwined with our ability to communicate, plan, and function in daily life. The project aimed to: 1. Investigate how individuals with aphasia understand time in language (Objective 1). 2. Explore whether time processing difficulties are specific to language or reflect broader cognitive impairments (Objective 2). 3. Identify the neural correlates of time comprehension through structural MRI analyses (Objective 3). An interdisciplinary approach was adopted, integrating neuro-linguistic theory, cognitive science, and neuroimaging techniques to provide a comprehensive understanding of time processing in aphasia.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Locating events on a timeline allows us to keep track of the past, live the present and plan the future. Some individuals can lose this fundamental aspect of human existence: aphasic patients. Aphasia is a language disorder typically caused by a stroke or a head injury that affects the ability to read, write and speak coherently. The source of the temporal impairment in aphasia is still unknown. Previous accounts focused on the linguistic aspect of this deficit, but data coming from clinical case reports and experimental studies suggest that this temporal impairment may not be exclusively linguistic. The main aim of this project is to carry out a systematic investigation of time processing in aphasic patients across different domains and, for the first time, through the use of structural magnetic resonance imaging. Three questions will be addressed: which aspects of time processing are impaired in aphasic patients? Is this impairment language-specific? What is the neurobiological basis of time processing? Behavioral (neurolinguistics/cognitive science) paradigms testing different aspects of non-/linguistic time processing will be combined with a voxel-based lesion-symptom mapping (VLSM) analysis and diffusion magnetic resonance imaging (dMRI). VLSM allows to analyze the relationship between lesioned grey matter and patients’ performance on a voxel-by-voxel basis, without the need of grouping patients based on lesion site or behavioral cut-off scores, while dMRI allows to explore which white matter pathways are also affected. Diffusion indexes will be also used to analyze the relationship between white matter fiber tract integrity and patients' performance. This proposal will provide answers to long-standing questions concerning the nature of the temporal impairment in aphasic patients and the neural underpinnings of time processing. This work will also lay the foundations for the development of new clinical tools for aphasic patients suffering temporal impairment.
Оригинален текст от CORDIS (на английски).
Участници
- BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE · San SebastianКоординаторИспания
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA · OaklandСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз
