H2020Индивидуална стипендия2021–2023

INKspired · Mimicking the dynamic and complex ECM: designing bioprinted immune-instructive hydrogels

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-15 → 2023-09-14
Финансиране от ЕС: 175 572 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Нови хидрогели, имитиращи структурата на тъканите, се разработват чрез комбиниране на две мрежи от материали. Те могат да помогнат за създаването на изкуствени органи и тъкани, за да се намали недостигът на донори за трансплантация.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Mimicking the dynamic and complex ECM: designing bioprinted immune-instructive hydrogels

The global demand for organ transplantation has increasingly exceeds the supply of donors. Organ shortage is now the limiting factor in treating many patients with chronic organ failure and has led to record numbers of patients on waiting lists. In Europe, over 150,000 patients have been registered on organ waiting lists in 2019, alone. Six new patients are added to this list every hour; the chronic lack of organs, tissues and cells has been attributed to over 18 patients deaths every day. In this context, the overall aim of the INKspired project is to generate novel ECM-inspired hydrogels, which could further recapitulate the dynamicity and complex structure of native tissue. By double network strategy, I will combine two dynamic hydrogel networks to control the overall mechanical and biological properties of constructs. This biomaterial design bridges multiple disciplines, from chemical synthesis and material science to engineering and biology, for creating advanced solutions in medicine. My research background, the guidance of Prof. Moroni and Dr. Baker (with a vast experience in biofabrication and biomaterials synthesis, respectively) and the ideal international setting (CTR, MERLN, UM) were fundamental for driving the multidisciplinary aspects of this proposal. Thus, this prestigious Marie Curie fellowship has boosted my professional career plan, by improving my research and advance publishing and communication skills, expanding my research network, developing administrative skills in project management, empowering me to take leading positions in the field of tissue engineering worldwide.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Tissue and organ shortage is the limiting factor in treating many patients with chronic organ failure and has led to over 18 patients deaths every day just in Europe. Recreating the 3D complexity of tissues and organs is moving step-by-step from sci-fi to reality thanks to the tremendous progress in 3D printing techniques. Native tissues and organs are composed of different cells, proteins, and signaling molecules that are arranged in a hierarchical complex microenvironment, called extracellular matrix (ECM). Bioprinting has emerged as a novel fabrication technique that assembles cells-laden biomaterials in a spatially controlled manner, promising customized 3D tissue-engineered constructs for potential clinical use. One of the main challenges to clinical success is to avoid immune system rejection. The overall aim of the INKspired project is to generate novel ECM-inspired bioinks, which could further recapitulate the dynamicity and complex structure of native tissue and even modulate the immune response. By double network strategy, I will combine two dynamic hydrogel networks to control the overall mechanical and biological properties of printed constructs. The outcomes of INKspired aim to contribute to tissue bioprinting and hence the global chronic lack of tissues.My unique research background, which includes tissue engineering, material science and engineering, will allow me to carry out this multidisciplinary project. I will collaborate with the supervisors, who have a vast experience in biofabrication and biomaterials, and work at the international and interdisciplinary setting (MERLN, Maastricht University). Marie Curie fellowship will enhance the potential of my future career perspectives by providing an interdisciplinary and translational education program, empowering me to take leading positions in the field of tissue engineering worldwide.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITEIT MAASTRICHT · MaastrichtКоординаторНидерландия