H2020Индивидуална стипендия2021–2023

I-SENS · Integrating SENSorimotor disorders with ankle hyper-resistance in cerebral palsy

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-10-01 → 2023-09-30
Финансиране от ЕС: 190 681 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Взаимодействието между нервната система и мускулите при хора с церебрален парализа се анализира, като се проследява как сковаността в глезените влияе на ходенето. Разбирането на тези процеси помага за подобряване на клиничните методи за лечение и качеството на живот на пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Integrating SENSorimotor disorders with ankle hyper-resistance in cerebral palsy

This project explored challenges faced by individuals with cerebral palsy, a condition affecting both the nervous and musculoskeletal systems. The main goal was to understand how these systems interact and impact walking ability in people with cerebral palsy, a prevalent childhood condition with lifelong effects. Given the absence of a cure, cerebral palsy leads to persistent motor difficulties, significantly affecting life quality and incurring substantial costs. Improving clinical treatments is crucial, and this project aimed to unveil fundamental insights for innovative approaches. It focused on three main objectives: 1) understanding the relationship between the motor and sensory systems, 2) exploring how muscle and bone features affect walking, and 3) figuring out the unique contributions of each system to walking ability. New mechanisms relating musculoskeletal properties and gait performance were unveiled, while processing for extracting motor and sensory system data is still underway.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Walking requires interactions among a central unit (motor system), actuators (musculoskeletal system) and real-time feedback (sensory system). When a brain lesion occurred, such as in cerebral palsy (CP), this is reflected to these systems. With this proposal, I aim to understand how the impaired system interaction affect walk ability. CP is the most predominant childhood disability. This disability is generally defined mainly as motor impairment, but it is known to be associated with somatosensory disorders. The sensory system is composed by sensation and perception. Here the perception will be assessed as cortical proprioceptive processing using MEG. The motor system will be analysed at the spinal level and in terms of resistance to passive ankle movement (neural and non-neural components of spasticity), whilst the lower limb musculoskeletal properties are quantified as morphology, stiffness and composition. I will focus on three objectives: (1) to unveil the interaction between spasticity and cortical proprioceptive processing, (2) to establish methodologies for extracting lower limb musculoskeletal properties and associate them with gait ability; (3) to understand whether is possible to delineate a statistical model that describes how altered motor, musculoskeletal and sensory systems at the ankle joint level affect gait ability. I will quantitatively analyse CP as sensorimotor disorder, thus opening new scientific and clinical frontiers.To successfully perform this project, I established a cooperation between myself and experts in musculoskeletal (my supervisor Prof. Taija Finni) and sensorimotor (Assoc.Prof. Harri Piitulainen) systems at the host institution. Their knowledge, their research teams and the facilities available will allow me to perform the planned study. Moreover, I will exploit the collaboration with KTH Stockholm during my secondment for comprehensively analyse musculoskeletal properties to become an independent professional.

Оригинален текст от CORDIS (на английски).

Участници

JYVASKYLAN YLIOPISTO · JyvaskylaКоординаторФинландия