H2020Индивидуална стипендия2022–2025

SPHELECTRO · Flexible electronics integrating 3D nanostructured electrodes for cellular-resolution in-depth electrophysiology recordings from developing spheroids and organoids

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2022-02-01 → 2025-12-24
Финансиране от ЕС: 295 062 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Гъвкава електроника с 3D електроди се разработва за дългосрочно проследяване на електрическата активност в лабораторни модели на човешкия мозък. Това помага за по-доброто разбиране на развитието на мозъка и механизмите при невродегенеративни заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Flexible electronics integrating 3D nanostructured electrodes for cellular-resolution in-depth electrophysiology recordings from developing spheroids and organoids

Three-dimensional neural models such as spheroids and organoids represent promising platforms for studying human brain development and neurodegenerative disorders, offering advantages for large-scale production and drug screening applications. However, current electrical characterization techniques remain limited to acute, invasive, or superficial recordings that fail to capture the long-term functional dynamics of these 3D structures. The SPHELECTRO project addressed this critical gap by developing a flexible electronics platform capable of seamless integration into 3D brain models for prolonged electrophysiological monitoring.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Three-dimensional neural models such as spheroids and organoids hold the potential to recapitulate several aspects of the human brain at the level of gene expression, cell differentiation, network and formation, thus representing one of the most promising technology to study brain development as well as neurodegenerative disorders. Suitable for large-scale production and genetic engineering, 3D brain models represent a highly encouraging model for next-generation drug screening assays. However, the electrical functionality assessment of such 3D models and its relevance to the human brain is still at its infancy, with current techniques limited to acute electrophysiology recordings through invasive or superficial tools. In this project, through the combination of expertise from the researcher in flexible neuroelectronics and surface functionalization, and from the host in nanotechnology-based electrophysiology and iPSC organoids, the overall scientific objective of the SPHELECTRO project is to develop a Seamless Array of Flexible Electronics (SAFE) with 3D nanostructured electrodes, integrated into 3D matrix-free brain models (spheroids and organoids) during early stages of development for prolonged, routine electrophysiology recordings with cellular resolution. This original proof-of-concept would provide an exceptional tool for the neuroscience community to advance our understanding of brain development and neurological disorders, with high industrialization potential in the pharmacology field. The timeliness and high interdisciplinarity of this project, at the intersection of fast-growing research topics such as flexible electronics, nanotechnology and organoids, will greatly build up skill transfer between the host laboratory and the researcher, as well as to enable the latter to establish a unique research profile towards the perspective of becoming a group leader in the field.

Оригинален текст от CORDIS (на английски).

Участници

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisКоординаторФранция