H2020Индивидуална стипендия2021–2023

CAJAL · OsteoCalcin Autophagy to reJuvenate motoneuronAL function

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-06-01 → 2023-05-31
Финансиране от ЕС: 184 708 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Хормонът остеокалцин, произвеждан от костите, и неговото влияние върху почистването на клетките (автофагията) в двигателните неврони се анализират. Това помага за разбирането на причините за влошаване на движението при стареене и търсенето на нови терапии за поддържане на физическите функции.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

OsteoCalcin Autophagy to reJuvenate motoneuronAL function

The action “Osteocalcin Autophagy to rejuvenate motoneuronal function” analyzed the role of systemic factors, focusing on how the bone-borne hormone osteocalcin is crucial for maintaining locomotion during ageing. This topic has crucial societal relevance as life expectancy is expected to increase, and ageing is associated with a decline in tissue performance, leading to impaired physiological functions. However, the process that leads to motoneuron dysfunction and locomotor performance decline remains largely unknown, and there are no available/on-going therapies to slow it down. Therefore, discovering novel anti-ageing pathways in neurons may pave the way for novel therapeutic strategies to prevent/treat the age-related decline of our locomotor functions. Prior to CAJAL, several studies have highlighted the importance of circulating factors in maintaining of optimal nervous system functions such as cognitive fitness, but none of them have unraveled the role of these factors in locomotion. The overall aim of CAJAL has been to be the first study to elucidate the impact of the systemic factors/Osteocalcin on spinal cord motoneurons, and to evaluate its therapeutic potential to prevent and/or treat age-related decline of motor function. Specific objectives have been: 1) Characterize the impact of systemic milieu/Ocn in regulating autophagy in spinal motoneurons; 2) Analyze the therapeutic potential of Ocn in age-related locomotor decline; 3) Decipher the role of Ocn-dependent autophagy in locomotor function and its signaling pathway. A parallel aim of the action, but of equal relevance, has been to foster the Fellow's research trajectory and pave his way for the further development of his career.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Brain aging is characterized by a progressive decline of our nervous system functions. Elucidating the underlying mechanisms is of vital importance and represents an unmet medical need. Recent studies have highlighted the molecular contribution of several organs in brain aging, and emphasize the importance of systemic milieu in the control of cognitive fitness. Host has identified Osteocalcin (Ocn), a bone-derived hormone, as a rejuvenating systemic factor that improves memory in aged-mice. However, the impact of systemic factors in our locomotor functions and their therapeutic potential remain unexplored.CAJAL aims to elucidate the role of the pro-rejuvenating hormone Ocn in the age-related motoneuron (MN) and locomotor dysfunctions. Our preliminary data show that Ocn receptor is highly expressed in spinal MNs and that Ocn influences MN autophagy, an essential endogenous mechanism for locomotor performance. We propose to analyse the potential protective role of Ocn-autophagy in MNs to maintain locomotor activity. By shedding light on key molecular mechanisms fostering MN homeostasis, CAJAL could lead to new therapeutic strategies to treat/prevent age-related decline of locomotor system.The specific objectives are:1) Characterize the impact of systemic milieu/Ocn in regulating autophagy in spinal MNs2) Analyze the therapeutic potential of Ocn in age-related locomotor decline3) Decipher the role of Ocn-dependent autophagy in locomotor function and its signalling pathwayThe project is designed to extend my scientific expertise and transfer my knowledge in autophagy and MN homeostasis to Host. Project and risk management, intellectual property rights, and communication activities are meticulously planned. We have generated the required molecular tools and mouse models, as well as strong collaborations with international experts in autophagy, neuroendocrinology and aging. Supervisor experience together with INEM represent the best environment to develop CAJAL.

Оригинален текст от CORDIS (на английски).

Участници

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisКоординаторФранция