H2020Индивидуална стипендия2021–2023

AMBIT · Additive Manufacturing of Magnesium Bioresorbable ImplanTs

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-01 → 2023-08-31
Финансиране от ЕС: 196 591 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Биоразградими импланти от магнезий за лицето и черепа се създават чрез 3D принтиране с ниска температура. Те могат да заменят титановите импланти, за да се избегнат повторни операции за тяхното отстраняване и да се подобри възстановяването на пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Additive Manufacturing of Magnesium Bioresorbable ImplanTs

Craniomaxillofacial defects (congenital or acquired) of the face, skull and jaw, are severely debilitating, where the patient not only suffers physically but also psychologically. Craniofacial conditions are often complex, affecting both soft tissue and the bones of the face and/or the head. Currently, non-resorbable implants are being used to address craniofacial defects where a second operation is routinely required to remove these devices with limited patient-specific customisation, that may lead to stress-shielding, long-term erosion, infection or lack of growth, particularly in vulnerable paediatric population. The AMBIT project allowed us to go one step closer to the realisation of customised Biodegradable Magnesium Implants for craniomaxillofacial applications to overcome the limitations of current clinical gold-standard non-resorbable Titanium (Ti)-based implants. Potential use of low temperature additive manufacturing (AM) technology is investigated for processing patient specific Mg-based implants. Further advancement of clinical implementation and use of patient specific Mg-based biodegradable implants will not only improve the post-operation experiences and lives of craniofacial implant recipients but ultimately decrease the cost burden on national health systems. Through AMBIT, new bioresorbable Mg alloys that are more suitable to process via low temperature AM technology were developed. High-quality FDM-compatible 3D-printing filaments containing Mg powder that are not currently available commercially were designed and processed. Preliminary experiments for the demonstration of translational capacity in exemplar craniofacial implant applications was demonstrated.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Congenital anomalies, affecting 6% of all babies, are a major cause of infant mortality and childhood morbidity, of which craniomaxillofacial (CMF) anomalies are often a component part. CMF defects are severely debilitating, where the patient not only suffers physically but also psychologically. CMF implants are used to facilitate and accelerate the healing process upon which a second operation is routinely required to remove these devices as most implants comprise of non-resorbable materials (Titanium-Ti, PEEK), with limited patient-specific customisation, that may lead to stress-shielding, infection or lack of growth, particularly in vulnerable paediatric population. The AMBIT project aims to optimise and customise Bioresorbable Magnesium Implants (BMgI) for CMF applications, to overcome the limitations of current clinical gold-standard non-resorbable Ti-based implants. This action combines my expertise in metallurgy and alloy design with Dr. Eoin O'Cearbhaill’s (UCD Centre for Biomedical Engineering (CBE)) and Dr. Ted Vaughan’s (NUIG) expertise in medical device development, testing and translation. This highly interdisciplinary approach will make a significant contribution to the development of bioresorbable CMF implants that will not only improve the post-operation experiences and lives of CMF implant recipients but ultimately decrease the cost burden on national health systems. Through advanced and well-designed training in research (medical device design, cell-studies for biocompatibility, 3D-Printing) and transferable skills (project management, mentorship, entrepreneurship) that go beyond my current field of specialty, and through the networking opportunities that the host will offer, this action will facilitate my reintegration in Europe, while allowing me to become a research leader in biodegradable Mg alloy design & processing for medical device applications, translating alloy design concepts from ideation to clinical use.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN · DublinКоординаторИрландия