H2020Индивидуална стипендия2021–2023

TBI-WAVES · Modelling and simulation of impact waves in brain matter

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-10-01 → 2023-09-30
Финансиране от ЕС: 184 591 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Механичните вълни в мозъчната тъкан и влиянието на течностите в нея се анализират чрез компютърни симулации при ударни травми. Това помага за по-доброто разбиране на причините за уврежданията и подобрява проектирането на нови хирургични техники и медицински продукти.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Modelling and simulation of impact waves in brain matter

The past decade has seen the emergence of numerous studies aimed at understanding the function of the brain and its behaviour. An important challenge lies in the prediction and the treatment of Traumatic Brain Injury (TBI), which is a major source of death and disability with huge human and financial costs. Using mechanics, consequential efforts have been dedicated to the mathematical description of the response of brain matter to forces. Huge resources have also been invested in the computer simulation of head injury scenarios. Further progress in these directions is of utmost importance to biomedical engineering, forensic science, and medicine, where numerical simulation is used to design new products and surgery techniques, and to understand the brain’s evolution after trauma. Experimental results suggest that head trauma could be linked to the development of shear shock waves in the brain, or to the focusing of shear waves at the centre of the brain. To better understand the mechanical processes behind brain damage, further research in this area is needed. To this end, precise knowledge of the mechanical response of brain tissue to dynamic loading is a key prerequisite. Reaching this goal requires in-depth study of wave propagation in soft solids. In this context, the TBI-WAVES project aimed at improving the mechanical and computational models of brain tissue, by • studying the influence of the fluid content on the motion of brain tissue based on the theory of porous media • investigating the mechanical causes of brain damage by following the phenomenology of TBI • developing advanced numerical methods for wave propagation simulations in brain matter These steps will pave the way towards the development of a high-performance computational framework for the simulation of head trauma.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

During the past decade, the brain has been the subject of numerous studies aimed at understanding its function and its behaviour. An important challenge lies in the prediction and the treatment of Traumatic Brain Injury (TBI), which is a major source of death and disability worldwide. In the mechanics community, important efforts have been dedicated to the mathematical description of the response of brain matter to forces, and to the simulation of traumatic events. Nevertheless, further progress is of utmost importance for applications in biomedical engineering and medicine. In facts, despite clear evidence that dynamic solicitations such as impacts play a crucial role in head traumas, several time-dependent effects are often neglected in the modelling (inertia, fluid content, viscous effects, swelling).The main goal of the TBI-WAVES project is to improve the mechanical and computational modelling of head traumas. A first aim is to improve the mechanical modelling of brain matter by accounting for the above commonly neglected effects. A second aim is to develop dedicated head impact simulation tools. The problem will be approached from theoretical and numerical perspectives, based both on the applicant’s and the host laboratory’s expertise. The training programme is exhaustive and will allow the applicant to grow as an independent researcher. The proposed research will foster further developments in this direction, a step which is fundamental in healthcare and for the benefit of society.The applicant is a Franco-German dual citizen, trained in France in applied mathematics, theoretical mechanics, and computational mechanics. He publishes articles in international scientific journals, with topics in applied mathematics and other disciplines. He is requesting funds for two years, to work within Prof. Michel Destrade’s team at NUI Galway. A six-month secondment at the University of Trento is planned.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF GALWAY · GalwayКоординаторИрландия