SAPTiMeC · Semi-Autonomous ProtoTissues capable of photo-Mechano-Chemical transduction
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-09-01 → 2023-08-31
- Финансиране от ЕС
- 176 656 €
- Участници
- 2
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Синтетични тъкани от изкуствени клетки се разработват така, че да променят обема си и скоростта на химични реакции при промяна на температурата. Това помага за разбирането на границата между живата и неживата материя и развитието на меката роботика.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Semi-Autonomous ProtoTissues capable of photo-Mechano-Chemical transduction
The main objective of SAPTiMeC was to create unprecedented tissue-like materials capable of self-regulating the amount of luminous energy received from the environment to tune their endogenous photocatalytic reactivity. The development of innovative and programmable tissue-like materials starting from synthetic components will provide key innovations that contribute to breakthrough knowledge in out-of-equilibrium materials, helping to bridge the gap between non-living and living matter. This work aimed to establish new areas in bottom-up synthetic biology by creating the first prototissues capable of higher-order functions. This research is also crucial for the development of emerging applications with impact in in tissue engineering, cell–protocell interactions (drug delivery, signalling, gene regulation), environmental remediation, soft robotics, and micro-bioreactor technology. Objectives of the research project: - Generation of large-scale prototissues with complex 3D architectures; - Development of phototropic prototissues; - Generation of prototissues capable of photo-mechano-chemical transduction. By applying the methods developed during this action, it was possible to build large-scale prototissues (also called protocellular materials, PCMs) starting from adhesive protocell building blocks. The PCMs were developed to encapsulate a synthetic polymer network within the protocell building blocks to achieve robust PCMs which could reversibly change their volume and mechanical properties upon a temperature variation. It was also possible to include catalysts, such as enzymes, within the PCMs and achieve a modulation of the rate of the enzymatic reaction following a temperature variation, achieving a mechano-chemical transduction within these materials. Furthermore, it was possible to introduce an external control of the PCM movements using an light stimulus. We can conclude that the project achieved most its objectives and milestones for the period.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Recently, researchers in the field of bottom-up synthetic biology have developed different models of non-living cell-like entities, termed protocells. Protocells are designed to mimic basic aspects of living cells and have potential applications in various emerging technologies. Prototissues comprise networks of protocell consortia that communicate and display synergistic functions. Though the current designs contribute much to the development of bottom-up synthetic biology, they lack robustness and the complexity required to perform higher-order functions. The aim of this proposal is to advance the prototissue design to create prototissues capable of higher-order functions (i.e. photo-mechano-chemical transduction). The prototissues will be created by stratifying and patterning populations of specialised protocells. As a result, the prototissue will be able to self-regulate the amount of luminous energy received from the environment by opening and closing cyclically. This movement enables the prototissue to tune its endogenous photocatalytic reactivity, producing waves of an output chemical signal. The expertise of the applicant in photochemistry, materials and nanomaterials chemistry will be applied to the emerging field of prototissue engineering, area in which the hosting supervisor is an emerging leader. The approach will be focussed on the generation of macroscopic free-standing prototissue sheets with complex architectures. This process will be used to create phototropic prototissues upon exploiting photoresponsive hydrogels encapsulated in their building blocks. The resulting phototropic prototissues will be modified in order to contain building blocks with photocatalytic synthetic proto-organelles. Collectively, the outcome of this proposal will: kickstart a new area of bottom-up synthetic biology; provide a new approach to the construction of out-of-equilibrium systems; and deliver new materials with applications in tissue engineering and soft robotics.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITA DEGLI STUDI DI TRIESTE · TriesteКоординаторИталия
- UNIVERSITY OF BRISTOL · BRISTOLОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз