H2020Индивидуална стипендия2022–2024

NuMA_CyclinB1_EM · Understanding the role of CyclinB1-NuMA interaction in spindle orientation and epithelial morphogenesis

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2022-09-01 → 2024-08-31
Финансиране от ЕС: 160 932 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Взаимодействието между протеините CyclinB1 и NuMA определя посоката, в която се делят епителните клетки при формирането на органи. Разбирането на този механизъм помага при изучаването на раковия процес и начина, по който се развиват или регенерират тъканите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Understanding the role of CyclinB1-NuMA interaction in spindle orientation and epithelial morphogenesis

Cell division is controlled not only in time, but also in orientation. Our aim is to advance knowledge on how cell cycle regulates spindle positioning, crucial to orientate cell division. Specifically, this research aims to elucidate the role of CyclinB1 in the formation and orientation of the mitotic spindle and its contribution to epithelial morphogenesis through its interaction with NuMA. Therefore, our mains objectives are finding how, when, where and why CyclinB1 and NuMA interact. I propose a multidisciplinary project to understand better the molecular mechanisms associated with cell division, spindle regulation, and its implication in epithelial morphogenesis. The cell cycle is intimately involved in all biological organisms' growth, development, reproduction, and aging; therefore, gaining insight into cell cycle controls will benefit the large community of biologists and medical sciences. Furthermore, establishing the correct orientation of the mitotic spindle is an essential step in epithelial cell division to ensure that epithelia tubes from correctly during organ development and regeneration. Disrupting of any of the spindle factors, could lead to aneuploidy, epithelial to mesenchymal transition and tissue disorganization. Moreover, a better understanding of mammalian cell cycle controls has significant potential to change medical treatments for cancer cells that have escaped the normal controls on growth and division in multicellular animals. Providing novel insights into cell cycle regulation and its implication in epithelial morphogenesis could potentially lead to therapies and treatments that could dramatically improve the economy's well-being, health, and creative output. Potential public sector health benefits would be realized over a more extended period.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

In multicellular organisms, oriented cell divisions sustain tissue morphogenesis, tissue architecture and homeostasis by ensuring the correct positioning of daughter cell after mitosis. Accurate execution of oriented divisions and chromosome segregation relies on the positioning of an essential actor, the mitotic spindle. The consequence of spindle misorientation is drastic. Disruption of any of the spindle orientation factors could lead to genetic instability, tissue disorganization and tumorigenesis. However, cell division is controlled not only in orientation, but also in time. Indeed, spindle orientation is also very important for a wide range of developmental processes, ranging from germline stem cell division to epithelial tissue homeostasis and regeneration. A more complete understanding of how spindles are oriented will therefore require more extensive research, e.g. using CRISPR-based strategies to interrogate the proposed interactions in vivo, into how the spindle-orienting machinery is localized and regulated in multiple systems. The aim of this project is to advance knowledge on how cell cycle regulates spindle positioning and its contribution in epithelial morphogenesis in the intestinal tissues. This advance knowledge will serve to better understand the pathogenic mechanisms of important human diseases such as cancer.

Оригинален текст от CORDIS (на английски).

Участници

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridКоординаторИспания