H2020Индивидуална стипендия2021–2023

REINFORMATION · engineering ligand-REceptor INteractions FOR Molecular communicATIONs

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-12-01 → 2023-11-30
Финансиране от ЕС: 145 356 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Молекулярната комуникация изследва как информацията се предава чрез взаимодействието между лиганди и рецептори, подобно на начина, по който клетките си „говорят“. Разбирането на тези процеси помага за създаването на системи за непрекъснат здравен мониторинг и прецизна доставка на лекарства в тялото.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

engineering ligand-REceptor INteractions FOR Molecular communicATIONs

The transmission of information through molecules is a fundamental aspect of nature, underlying collective behaviour, homeostasis, and numerous disorders and diseases. It could hold answers to some of life’s most profound questions. Understanding and engineering this natural communication method, namely Molecular Communications (MC), offers the potential to revolutionize various research fields, including healthcare, computing, and micro/nanorobotics. MC holds promise for novel applications such as continuous health monitoring, smart intrabody drug delivery, and wetware artificial intelligence, all of which could have substantial societal and economic impacts. The main objective of the project was to understand, optimise, and engineer Ligand-Receptor (LR) interactions for high data-rate and reliable MC systems. LR binding interactions are fundamental to natural MC systems, ensuring selective information transfer. These interactions are equally crucial in artificial MC systems to ensure selective and reliable communication. Building upon this understanding, the project’s specific objectives were to: (i) develop an experimentally validated theoretical framework for micro/nanoscale MC; (ii) create an experimental validation platform for micro/nanoscale MC; (iii) optimize and engineer LR interactions for high data-rate MC; and (iv) develop practical MC techniques for high data-rate applications.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Molecular Communications (MC) is the nature’s way of networking at nanoscale, observed in almost all biological systems, including bacterial populations and nervous system. MC has been widely studied to enable the networks of artificial nanoscale devices promoting new high-impact applications such as intrabody continuous health monitoring with mobile nanosensor networks. At the core of the natural MC systems lies the ligand-receptor (LR) binding interactions, which provide the selectivity of information transfer. Likewise, LR interactions are essential for artificial MC systems to have a selective and reliable channel/receiver interface in the form of a biorecognition layer consisting of ligand receptors. Recent studies have revealed the dramatic impact of LR interactions on the overall MC performance in terms of channel bandwidth, molecular interference, receiver sensitivity and dynamic range, posing a multi-objective optimisation problem. The aim of REINFORMATION is to understand, optimise and engineer the LR interactions for high data-rate and reliable MC systems. To this end, the project will first deliver a realistic theoretical modelling and optimisation framework for MC accompanied by a microfluidic experimental test and validation platform with graphene aptasensor-based MC receivers. The framework will provide the first experimentally validated micro/nanoscale MC models, and enable the optimisation of binding affinity and kinetic rates of LR interactions from the MC perspective. The optimisation results will guide the rational design of new aptamer receptors for target information-carrying proteins, which will then be implemented on the experimental platform. The project will finally provide novel MC modulation and detection techniques, exploiting the LR interactions for high data-rate and reliable MC. Combining expertise in MC, nanotechnology, and computational biology, the project will remove a major barrier to the development of practical MC applications.

Оригинален текст от CORDIS (на английски).

Участници

KOC UNIVERSITY · IstanbulКоординаторТурция