H2020Индивидуална стипендия2021–2023

MiTuMi · Bioengineered Matrices Mimicking the Lung Tumor Microenvironment

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-05-01 → 2023-04-30
Финансиране от ЕС: 145 356 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Биоинженерни модели имитират 3D структурата и средата около туморите в белия дроб. Те помагат за по-доброто разбиране на механизмите, при които се развива болестта, тъй като животните и стандартните лабораторни култури не винаги отразяват точно човешкия организъм.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Bioengineered Matrices Mimicking the Lung Tumor Microenvironment

Lung cancer is the primary cause of cancer-related mortality despite advances in early diagnosis and next-generation therapeutics. Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. Non-small cell lung cancer (NSCLC) comprises over 80% of total lung cancer cases and affects both smoking and non-smoking populations. There is a vital need for a better understanding of the biological mechanisms that govern the onset and progress of this grave disease. Cancer research has been mainly led by animal models and conventional two-dimensional (2D) culturing of tumor cells in order to both investigate disease-mediating signaling events and testing of therapeutics. However, animal models do not always successfully predict the course of the disease or drug responses seen in humans. 2D culturing of tumor cells on the other hand, fail to represent the 3D structure and extracellular matrix (ECM) of native organs and tissues which have crucial roles in enabling cell-cell and cell-matrix interactions. The importance of the tumor microenvironment with tumor-specific ECM components and a crowded cast of different cell types which chaperon tumor cells has been recently appreciated in the field. This calls for engineering approaches which aim to develop biomimetic and physiologically relevant preclinical models for cancer research. This action aims to determine the key aberrant aspects of the lung tumor ECM and develop tissue engineered human in vitro lung tumor models which enable investigation of their biological roles on the formation and progression of disease.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Lung cancer is the leading cause of cancer-related mortality in the world. It most often gets diagnosed at an advanced stage with a 5-year survival rate as low as 5%. Despite recent advances in development of therapeutics, lack of a comprehensive understanding of the complexity and dynamicity of the tumor microenvironment hinders effective clinical outcome. Tumor microenvironment plays a crucial role in tumorigenesis and subsequent disease progression leading to metastasis as well as resistance to therapeutics. Conventional monolayer culturing of tumor cells fails to recapitulate the essential microenvironmental aspects of native tumors whereas mouse models suffer from limited relevance, high cost and low throughput. A three-dimensional (3D) human in vitro tumor model that faithfully mimics the tumor microenvironment is key to advance the current understanding of biological processes and signaling pathways that govern these complex pathological events. I propose a biomimetic human lung tumor model that allows independent tunability and control of aberrant biochemical and mechanical aspects of the tumor microenvironment to study cellular events that govern tumorigenesis (Objective1), metastasis and drug resistance (Objective2) and patient heterogeneity (Objective3). Following a highly interdisciplinary approach where tissue engineering, material science, medicine and molecular biology converges, the implications of a tunable and biomimetic 3D human tumor model is substantial for the future of precision-medicine and development of patient- specific therapeutic regimens.

Оригинален текст от CORDIS (на английски).

Участници

KOC UNIVERSITY · IstanbulКоординаторТурция