H2020Индивидуална стипендия2021–2023

NERVASION · Targeting microenvironment of cancer-invaded-nerves in pancreatic adenocarcinoma.

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-06-01 → 2023-05-31
Финансиране от ЕС: 191 149 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Клетъчната среда около нервите, които са проникнати от рак на панкреаса, се анализира чрез модерни технологии. Разбирането на тези механизми може да помогне за откриването на нови мишени за терапия при този агресивен вид тумор.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Targeting microenvironment of cancer-invaded-nerves in pancreatic adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumour with a poor prognosis, a high mortality rate, and no effective therapies. One of the pathological hallmarks of PDAC is the infiltration of cancer cells along nerves and within nerve fibres. Nerve invasion is present in many solid tumours, but its prevalence is highest in PDAC, ranging between 70% and 98%. It occurs early during PDAC development and is associated with increased tumour recurrence, enhanced metastasis, decreased overall survival, and a highly pro-tumorigenic immune microenvironment. The cellular and molecular mechanisms acting within cancer-invaded nerves to promote tumorigenesis remain unknown, precluding novel therapeutics development. In this project, we applied cutting-edge technologies to human pancreatic adenocarcinoma tissues and profiled the microenvironment of cancer-invaded nerves. We identified cellular and molecular players acting within cancer-invaded nerves, and the functional role of identified factors in cancer proliferation and invasiveness will soon be tested with in vitro and in vivo assays. In the long term, the results of the project might identify novel therapeutic targets for PDAC.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Pancreatic ductal adenocarcinoma (PDAC) is an exceptionally aggressive cancer with a 5-year survival rate below 10%. It is resistant to traditional treatments and unresponsive to immunotherapy. New insights into the biology of PDAC are needed to identify novel therapeutic targets. Nerve invasion, defined as the presence of cancer cells along nerves and within different layers of nerve fibres, is a hallmark feature of PDAC. Patients that show signs of nerve invasion have a worse prognosis, higher risk of tumour recurrence, and suppressed anti-tumour immune responses. During PDAC, nerves form a dynamic microenvironment in which glial cells, neurons, stroma cells, cancer cells, and immune cells interact. The mechanistic basis of this communication and its effects on cancer progression remain undefined. Thus, in this project, cutting-edge transcriptomics technology preserving spatial information will be applied to human and murine PDAC tumour tissue sections. The cellular and molecular pathways dysregulated explicitly within cancer-invaded nerves will be identified, and the therapeutic potential of their targeting will be controlled in vitro and in vivo. The findings generated within this project could provide novel treatment strategies for PDAC and essential insights into the basic biology of cancer-nerve-immune interactions during tumorigenesis.

Оригинален текст от CORDIS (на английски).

Участници

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH · ZuerichКоординаторШвейцария