H2020Индивидуална стипендия2021–2024

CanSENS · Colon Cancer Breath Screening using Nanowire-SERS

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-06 → 2024-09-15
Финансиране от ЕС: 145 941 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Устройството за анализ на дъха използва специална спектроскопия, за да открива рак на дебелото черво в ранен стадий. Това е важно, защото предлага бърз и безболезнен метод за диагностика, който е по-лесен за пациентите от традиционната колоноскопия.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Colon Cancer Breath Screening using Nanowire-SERS

According to the World Health Organisation (WHO), cancer is the second leading cause of death globally, claiming one in every six lives. Colon cancer (CoC) is the most common cancer affecting both males and females, with a predicted morbidity rate of 75% by 2040. CoC patients remain asymptomatic in the early stages of the disease, with symptoms typically detected only at advanced stages (stages 3 and 4), leading to a high mortality rate (50%). Currently, the most effective clinical method for the detection of CoC is colonoscopy, a time-consuming and non-invasive procedure. This gold standard technique requires experienced medical personnel, has high procedural costs, causes discomfort to most patients, and carries the possibility of iatrogenic trauma. Other clinical non-invasive imaging techniques are available (i.e. MRI, PET/CT), however they are often prone to misinterpretation due to the presence of heterogeneous artifacts, and are typically reserve for verification and differential diagnosis. A low-cost, rapid, non-invasive, and accurate screening technique is highly important for the early diagnosis of asymptomatic cancers and increase of the survival rate, especially in health systems of low- and middle income countries. The CanSENS research project aims to develop a breath analysis device for early stage CoC screening based on Surface-Enhanced Raman Spectroscopy (SERS). This device will be engineered as a clinical diagnostic assay, aimed toward the developments of a universal breath analysis platform, which can potentially be expanded to detect other cancers or diseases. Therefore, collecting exhaled breath samples from patients is easy, non-invasive, pain-free, and suitable for critically ill patients (i.e. in intensive care units) or children. The proposed non-invasive SERS-based gas-sensing device has the prospect of being used as supplementary technique to the primary screening method currently being used in cancer diagnosis globally. This will allow a further increase of detection at early stages (stage 1 and 2) of the disease and effectively reduce its mortality rate. The overall objective of the project is the development of a low-cost SERS-based gas-sensing platform with the goal of enabling screening of early stage CoC via an annual routine doctor visit, as well as monitoring treatment progression an recurrence in patients.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Conventional techniques for detecting colon cancer (CoC), such as colonoscopy, are invasive, costly, and time-consuming. Volatile Organic Compound (VOC) detection in patients’ breath, has emerged as a new non-invasive method to diagnose and assess cancer at early stages. The CanSENS project aims at the development of a non-invasive and cost-effective breath analysis sensor platform for early-stage CoC screening, based on Surface-Enhanced Raman Spectroscopy (SERS). The proposed objectives include the fabrication of a prototype SERS sensor with high sensitivity, selectivity, and specificity; the development of a numerical chemometric model to identify the target VOCs of CoC; and clinical validation via breath samples of cancer patients versus healthy individuals, allowing multivariate analysis. These objectives will be achieved by incorporating novel single-dimensional nanomaterials for strong and quantitative SERS signal, which will further enhance the Raman sensing capabilities. In order to increase the overall sensing surface area of the device (i.e. the SERS ‘hot spots’) and enable the detection of VOCs at low concentrations, the nanostructures will be self-assembled into networks using state-of-the-art printed electronic techniques, including dielectrophoresis. SERS-based chemometric analysis will be performed on patients’ breath samples, providing an understanding of the complex relationship between the VOC profile and CoC occurrence. This project is multidisciplinary and includes aspects of engineering, chemistry, and clinical diagnostics. The fellow will work closely with experts in both academic and clinical sectors, for the development of a universal breath analysis platform that can potentially be expanded to detect other cancers.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF CYPRUS · NicosiaКоординаторКипър