H2020Индивидуална стипендия2021–2024

DyeMetalloCage · Dye-Based Metallo-Supramolecular Cages for Molecular Recognition, Catalysis and Biomedical Applications

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-13 → 2024-01-13
Финансиране от ЕС: 172 932 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Металосупрамолекулярни клетки, създадени от специални багрила, се разработват за улавяне на молекули или ускоряване на химични реакции. Тези структури могат да служат като преносители на лекарства или инструменти за биовизуализация благодарение на разтворимостта си във вода и ниската им токсичност.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Dye-Based Metallo-Supramolecular Cages for Molecular Recognition, Catalysis and Biomedical Applications

The MSCA project is concerned with the design and development of cutting-edge metallo-supramolecular assemblies based on subphthalocyanines, BODIPYs and azaBODIPYs for various applications such as molecular recognition, catalysis, and biological studies. The applications stemming from the formation of host-guest complexes within 3D capsules are diverse and impactful. These 3D architectures, creating a distinctive environment and geometric constraint, open avenues for medical applications as drug carriers, molecular recognition for selective encapsulation, and catalytic chambers or nanocontainers for reactions. Subpthalocyanines (SubPcs), with their non-planar cone-shaped conformation and inherent chirality, present unique structural and photophysical features. Additionally, the BODIPYs, a versatile fluorescent dye with excellent properties, hold promise for bioimaging, biological labelling, and fluorescence assays due to their low toxicity and high photostability. In this context, the goal of this project (DyeMetalloCage) included the investigating on advancing of SubPc and BODIPYs metallo-supramolecular cage chemistry. This project aims to bring metallo-supramolecular chemistry to unprecedented levels of applicability, developing novel water soluble assemblies constructed through supramolecular tools as new materials for technologically- and biologically relevant functions. To achieve this, we decided to devolve water soluble SubPc and BODIPYs supramolecular cages/metallocycles and investigated them for catalytic and biological applications. Overall objectives are a) Synthesis of SubPc/azaBODIPYs ligands and their metallo-supramolecular assemblies. Standardization of synthetic route and purification technique to obtain the cages in appreciable yield; b) Investigate the ability of SubPcs metallo-supramolecular cages to serve as molecular receptors for the complexation of fullerenes and other molecules in water media. c) Assess the potential of these assemblies to create hydrophobic reaction environments in aqueous solutions, influencing and accelerating chemical reactions over fullerene species in an aqueous environment. This unexplored goal could have a significant impact on the scientific community. d) Investigate the potential of azaBODIPYs metallo-supramolecular π-amphiphiles to self-assemble into nanostructures. Explore their applications in biomedical contexts, leveraging their photosensitization capabilities for singlet oxygen generation, anticancer activity, and fluorescence properties.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The training program DyeMetalloCage(DMC) is an ambitious and well-designed project that has been conceived to make a ground-breaking impact within the interdisciplinary field of self-assembly, material science, nanochemistry, catalysis and biomedicine. This project is aimed at bringing metallo-supramolecular chemistry to unprecedented levels of applicability, developing novel assemblies constructed through supramolecular tools as new material for technology and biologically relevant functions. The proposal is focused on the preparation of cutting-edge metello-supramolecular assemblies based on subphthalocyanines, BODIPYs, and azaBODIPYs, and the study of their abilities to: (1) Behave as molecular receptors for the complexation of different fullerene derivatives in aqueous medium; (2) modify the reactivity and the kinetics of addition reactions over fullerenes in the interior of the cage; and (3) behave as supramolecular amphiphilic photosensitizers for biomedical applications.The applicant will gain new knowledge during the fellowship at the host organization. The training provided by the program will contribute to improve the development of his career in a number of ways. The highly multidisciplinary aspect of this project proposal will allow interaction with various experienced and young researcher different fields, including chemistry, physical chemistry and biochemistry. This will make a two-year long MSCA fellowship in the host group into an invaluable preparation for an independent professional career in academia or industry in near future. The training offered by the host group is of the highest quality, which is translated into the achievements and track record of former Ph.D. and postdoctoral students.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSIDAD AUTONOMA DE MADRID · MadridКоординаторИспания