H2020Индивидуална стипендия2021–2024

FuelHydrogel · Constructing chemically fueled hydrogels of polymers

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-11-01 → 2024-07-30
Финансиране от ЕС: 219 312 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Хидрогели от полизахариди се създават така, че да се поддържат чрез химическо „гориво“, подобно на процесите в живите организми. Това помага за разработването на материали с контролируеми свойства, които могат да се използват в химията и биомедицината.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Constructing chemically fueled hydrogels of polymers

Most synthetic materials are close to or reside in equilibrium, however, life, the most ‘intelligent materials’ on earth, always stays away from equilibrium. This non-equilibrium state is usually sustained by high-energy molecules (chemical fuels) harvested from metabolic reaction cycles. This has inspired the construction of chemically fuelled dissipative molecular assemblies. Currently, these chemically fueled systems mainly focus on small molecules. Compared to small molecules, polymers show advantages in constructing 3D-bulk materials, as well as, integrating and amplifying molecular-scale changes to visible macroscopic changes. We thus propose to extend the construction of dissipative assemblies from small molecules to polymers. The overall goal of the ´FuelHydrogel´ project is to construct chemically fuelled dissipative materials of polymers (polysaccharides) which are regenerative and accessible to spatiotemporal control. This new generation of materials could be used to address our challenges in materials chemistry and biomedicine. Moreover, this action will extend the research domain of systems chemistry from small molecules to polymers.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Most synthetic materials are close-to or reside-in equilibrium, however, life, the most ‘intelligent materials’ on earth, always stays away-from-equilibrium. This non-equilibrium state is usually sustained by high energy molecules (chemical fuels) harvested from metabolic reaction cycles. This has inspired the construction of chemically fueled dissipative molecular assemblies. Currently, these chemically fueled systems mainly focus on small molecules. Compared to small molecules, polymers show advantages in constructing 3D-bulk materials, as well as, integrating and amplifying molecular-scale changes to visible macroscopic changes. Thus, I propose to construct chemically fueled polymeric materials to overcome current limitations. A series of dextran-based chemically fueled hydrogels are constructed by coupling with appropriate analogue metabolic reaction cycles. The resulting hydrogels are responsive to chemical fuels and have the ability of self-healing and programmable decay. The life-time of the hydrogels is controllable by manipulating the kinetics of the reaction cycles. Controlled release of active ingredients (e.g. for drug delivery applications) from these hydrogels will be investigated. This fellowship will help me to reintegrate into the scientific community after maternity leave since 2017 in France. The project will be interdisciplinary as it ranges from the understanding of biological materials over polymer chemistry, systems chemistry, and organic chemistry to potential biomedical applications. It will also promote the two-way transfer of knowledge between me and the host.

Оригинален текст от CORDIS (на английски).

Участници

AALBORG UNIVERSITET · AalborgКоординаторДания