H2020Индивидуална стипендия2021–2023

FUNCrystals · Functional Organic Nanocrystals for Ultralong Phosphorescence Lifetime Bioimaging Applications

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-09-01 → 2023-08-31
Финансиране от ЕС: 224 934 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Органичните нанокристали от типа 4-DNB се изследват за използване при високоразрешаващо биовизуализиране. Това помага за разработването на по-безопасни материали за диагностика, изследване на болести и доставка на лекарства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Functional Organic Nanocrystals for Ultralong Phosphorescence Lifetime Bioimaging Applications

The FUNCrystals project addresses a multifaceted problem encompassing materials science, biomedicine, and advanced imaging techniques. Its core objective is to advance our understanding of room-temperature organic phosphor nanocrystals and their potential applications in biomedicne. Specifically, the project focuses on bulk 4-Diphenylamino-4'-nitrobiphenyl orgnaic crystal to Nanocrystals (4-DNB NCs), delving into their large scale synthesis, characterization, biocompatibility, and advanced imaging applications. The key aspects of the project can be summarized as follows: Materials Science Advancements: The project seeks to unlock the full potential of 4-DNB NCs by investigating their properties, particularly their optical and structural characteristics. By analyzing their behavior at the nanoscale, we aim to contribute to the development of novel materials with unique features and applications. Biocompatibility and Biomedical Relevance: Understanding the biocompatibility of 4-DNB NCs is crucial for their utilization in various biomedical applications. This research is significant for society as it can lead to the development of safe and effective nanomaterials for drug delivery, imaging, and other healthcare applications. Advanced Imaging Techniques: The project introduces cutting-edge imaging techniques, such as two-photon phosphorescence lifetime microscopy and two-photon excited fluorescence, to capture high-resolution, high-contrast images. This innovation has far-reaching implications for diagnostics, disease research, and the development of new imaging tools. The overall objectives are to advance the knowledge and applications of nanocrystals, contribute to the development of safer and more efficient materials for biomedicine, and revolutionize imaging techniques for enhanced biological and medical research. By the project's conclusion, we aim to have made substantial progress in each of these areas, ultimately benefitting society through scientific advancements and potential applications in healthcare and materials science.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Recently, organic room-temperature phosphorescence materials (ORTPs) have gathered tremendous interest due to their high brightness and ultra-long lifetime (ULL) features, and ORTPs are useful in many advanced applications, including optoelectronics, bioimaging(BI), and photomedicine. However, at this early stage of development, processing of nanoform ORTPs and scalable synthesis lag behind other forms of ORTPs, leaving the chances for many applications nearly uncharted. Thus, the FUNCrystals project aims to develop functional ORTP nanocrystals (NCs) for two-photon phosphorescence lifetime imaging microscopy (2P-PLIM) BI applications. In particular, the project proposes 3 main activities that capitalize on the strength of the proposed experienced researcher and the host research group (Prof. Clemens Kaminski), in ORTP-NCs synthesis and 2P-PLIM usage. 1.Develop a synthesis process to control the size and shape of ORTP-NCs with high emission quantum yield (QY) and ULL. 2.Investigate the nonlinear optical (NLO) properties and biocompatibility analysis of ORTP-NCs. 3.Use the ORTP-NCs as nanoprobes in the 2P-PLIM to capture the high spatiotemporal and high contrast image in the primary Epithelial cell lines. The expected results will exploit the size and shape-dependent properties of the ORTP-NCs, aiming to demonstrate property performances that can elicit commercial interest in potential nanoprobes for 2P-PLIM bioimaging applications. This project's success will make a substantial contribution to one of the European Union's main concerns on developing nanotechnologies and advanced materials. Overall, this proposed multidisciplinary project brings benefits to both the applicant and the host institution(University of Cambridge) in terms of mutual knowledge transfer, joint publications, new collaborations, networking actions, and personal career development of the researcher as well as increased public awareness about research resulting from the ambitious outreach actions.

Оригинален текст от CORDIS (на английски).

Участници

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEКоординаторОбединеното кралство