H2020Индивидуална стипендия2022–2024

MoRPHEUS · Motor Rehabilitation Plasticity Hacking by Engineered stimulation of the brain dUring Sleep-wake cycle

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2022-05-16 → 2024-05-15
Финансиране от ЕС: 183 473 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Електрическата стимулация на мозъка се синхронизира с цикъла на сън и будност, за да се подобри моторното възстановяване след инсулт или травма. Това е важно, защото много пациенти не възвръщат напълно ежедневните си умения чрез стандартна физиотерапия.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Motor Rehabilitation Plasticity Hacking by Engineered stimulation of the brain dUring Sleep-wake cycle

Brain lesions such as stroke and traumatic brain injury are a major cause of adult-onset disability. Physical therapy with robotic-aided rehabilitation is the gold standard for promoting motor recovery. Yet, half the affected individuals do not fully recover their daily living skills. Hope is provided by advanced neuroprosthetic devices, acting directly at the brain level to promote plasticity, but to date, they still fall short of producing long-lasting brain rewiring. The often neglected but close relationship between sleep, neural plasticity, pathogenesis, and motor recovery can constitute a key factor in advancing treatment. Thus, the EU-funded MoRPHEUS project aims to develop a novel neuroprosthetic approach that monitors brain activity and delivers electrical stimulation according to the sleep-wake cycle architecture. For this, the project pursued the following specific goals: 1. Investigate how brain lesions impact the neurodynamics and electrophysiological patterns of the SWC. 2. Develop a closed-loop system to monitor SWC and deliver precisely timed ES. 3. Use ES in coordination with SWC to induce therapeutic neural plasticity and promote motor rehabilitation. While the project remains in progress under the scope of different research programs, its scientific findings and technological advancements have been and still are being disseminated as peer-reviewed publications, contributions to open-source repositories, and communications at conferences. We expect that the technology developed in the project will benefit stakeholders in the neuroscientific and neuroengineering community, as well as physicians, medical staff, and patients in the midterm future.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Brain lesions such as stroke and traumatic brain injury are a major cause of adult-onset disability. Physical therapy, together with robotic aided rehabilitation, is the gold standard for promoting motor recovery. Yet, half of the affected individuals do not fully recover their daily living skills. Hope is provided by advanced neuroprosthetic devices, acting directly at the brain level to promote plasticity, but to date, they still fall short of producing long-lasting brain rewiring. The often neglected but close relationship between sleep, neural plasticity, pathogenesis, and recovery can constitute a key factor to advance treatment. Within this framework, the primary goal of this project is to devise and test a novel neuroprosthetic approach that monitors brain activity and the sleep-wake cycle (SWC) in order to deliver responsive and engineered electrical stimulation (ES) coded in time. To do this, we aim to: 1) investigate SWC architecture in animal models of brain lesion to better understand pathological modifications and to find privileged windows of neural plasticity to deliver therapeutic ES; 2) design, build, and test a closed-loop system capable of recording, processing and detecting SWC stages and electrographic events of interest (e.g. spindles), and also of delivering coordinated ES, including activity-dependent and time-coded stimulation, and; 3) evaluate the designed approach regarding its efficacy in providing long-lasting, robust, and safe motor rehabilitation to injured animals, while also obtaining a proof-of-concept in humans. Highly complementary skills from fellow and host will cooperate to carry in vivo electrophysiology experiments and technological development, while translational pilot experiments will be performed in close collaboration with partners in the medical field. Finally, secondments will provide additional training on state-of-the-art engineering of closed-loop systems and entrepreneurship in neurotechnology.

Оригинален текст от CORDIS (на английски).

Участници

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA · GenovaКоординаторИталия