H2020Индивидуална стипендия2021–2023

DESIRE · DESign of enzyme-InspiREd multivalent catalysts through functional patterning of nanosystems

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-06-01 → 2023-05-31
Финансиране от ЕС: 191 149 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Изкуствени катализатори от сребърни наночастици и пептиди имитират работата на ензимите при химични процеси като хидролиза на естер. Те позволяват провеждането на реакции в условия, в които естествените ензими не могат да функционират или са неефективни.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

DESign of enzyme-InspiREd multivalent catalysts through functional patterning of nanosystems

The development of artificial enzyme mimetics presents a highly promising approach to address certain drawbacks associated with natural enzymes, including their limited tolerance to varying experimental conditions, restricted substrate versatility, and limited adaptability to non-biological reactions. A recently emerged and potent strategy involves the self-assembly of peptides onto metal nanoparticles, enabling the creation of well-defined arrays of functional groups in a specific geometry and spatial arrangement. In the present project, we have successfully devised novel catalytic systems that mimic enzymes for aldol reactions and ester hydrolysis. These systems are based on silver nanoparticles coated with peptides, thereby demonstrating their efficacy as artificial catalysts.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Developing artificial enzyme mimics represents a promising strategy to overcome some of the limitations of enzymes such as low tolerance to experimental conditions, poor substrate versatility or poor adaptability to abiotic reactions. Supramolecular approaches to creating organized ensembles of molecules allowed for constructing enzyme-mimicking assemblies displaying collective properties in terms of affinity and reactivity. Despite these advances some critical challenges, such as achieving synergy between multiple functional and structural components to enhance the catalytic performance and selectivity of artificial enzyme-mimics, remain untackled. Self‐assembly of peptides on the surface of metal nanoparticles has recently emerged as a powerful strategy towards creating arrays of functional groups in a defined geometry and space. This strategy provides the opportunity to induce cooperativity between the functionalities in the assembly which would be a highly sought for property in an enzyme-mimicking system. The proposed DESIRE project aims at developing new enzyme-mimicking assemblies where a supramolecular approach is used to preorganise simple catalytic units in order to achieve enzyme-like efficiency and selectivity. The designed enzyme-inspired multivalent catalysts will be obtained by a fine-tuning involving orientation, local hydrophobicity and spatial proximity of amino acids and short peptide ligands which coated on the surface of monolayer-protected nanoparticles or embedded within functional polymers. This should allow to create hydrophobic regions decorated with catalytic moieties in the nanostructures reminiscent of the catalytic pockets in enzymes. The catalytic performance of the constructed systems will be evaluated in selected chemical transformations: aldol reaction and cleavage of ester bonds.

Оригинален текст от CORDIS (на английски).

Участници

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH · ZuerichКоординаторШвейцария