H2020Индивидуална стипендия2022–2024

BrainTree · Evolution of neuroanatomical diversity: A phylogenetic comparative analysis across vertebrates using MRI.

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2022-02-01 → 2024-01-31
Финансиране от ЕС: 196 708 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Еволюцията на мозъка при над 150 вида гръбначни се анализира чрез ЯМР изображения, за да се проследи как се появяват сложните гънки и форми. Това помага за по-доброто разбиране на организацията на човешкия мозък и неговата естествена или патологична вариативност.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Evolution of neuroanatomical diversity: A phylogenetic comparative analysis across vertebrates using MRI.

The study of brain evolution allows us to better understand the emergence of brain organisation, providing a unique perspective on the natural and pathological variability of the human brain – a major challenge for neuroscience. But comparative anatomy data are rare: Only a few species – mostly mice and humans – focus most research efforts, and building bridges between them is not trivial. Project BrainTree addressed this by studying brain evolution across more than 150 species using neuroimaging and phylogenetic comparative methods, focusing on folding and mechanical morphogenesis – the emergence of complex shapes from physical instabilities triggered by growth. The project aimed to analyse neuroanatomical variation, test evolutionary models, and explore vertebrate brain evolution, shedding light on the emergence of brain organisation at multiple levels. Grounded in open science and collaboration, BrainTree created a large open database of vertebrate brain MRI and histological data and a framework for distributed collaboration in comparative neuroscience. By studying the evolution and conservation of neuroanatomy, the project shed light on how brain size, surface area and folding evolved, how current diversity emerged and what the brains of the common ancestors of primates and mammals likely have looked like.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The study of the evolution of the brain across species provides a unique perspective on the sources of normal and pathological variability in the human brain – a major challenge for neurosciences today.I propose a project to study the evolution of the vertebrate brain with unprecedented detail. I have a strong background in neuroimaging, computational neuroanatomy and the creation of platforms for real time collaboration in neuroimaging. During the last years I have worked on the analysis of the neuroanatomical development of the human brain and the evolution of primate brain folding, as well as in the development of Web tools to allow distributed collaboration among scientists. I propose to use this expertise to build the largest, open database of magnetic resonance imaging data of vertebrate brains. I will use state of the art computational neuroanatomy methods to build precise brain reconstructions and automatically extract a series of neuroanatomical measurements of regional brain volume, surface-based shape information and brain folding. In addition, I will develop new methods to capture the variability in shape and folding patterns using graph theory and deep learning algorithms. I will test different evolutionary scenarios using phylogenetic comparative methods, to estimate ancestral phenotypes, evolutionary changes, and the emergence of multivariate relationships across brain structures.My project will be developed in collaboration between the Group of Theoretical and Applied Neuroanatomy at Institut Pasteur, the National Natural History Museum in Paris and the Institute of Biology of the École Normal Supérieur. This collaboration will provide the ideal framework for my project, combining the availability of one of the world’s largest vertebrate brain collections, with leading expertise in computational neuroanatomy and phylogenetic comparative methods, crucial for my future career goal of becoming a leading researcher in brain evolution.

Оригинален текст от CORDIS (на английски).

Участници

INSTITUT PASTEUR · ParisКоординаторФранция