H2020Индивидуална стипендия2021–2023

DermPlast · Assessment of human Dermal exposure to microPlastics additive chemicals and the risk arising from such exposure using innovative 3D-human skin equivalents

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-11-03 → 2023-11-02
Финансиране от ЕС: 224 934 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Микропластмасите и съдържаните в тях токсични вещества, като огнеупорните химикали, се изследват чрез 3D модели на човешка кожа. Това помага за по-точна оценка на рисковете за здравето и създаване на по-добри регулации за безопасност.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Assessment of human Dermal exposure to microPlastics additive chemicals and the risk arising from such exposure using innovative 3D-human skin equivalents

DermPlast aims to address a significant research gap represented by the lack of information on human exposure to toxic additive chemicals in Microplastics, especially as it relates to dermal exposure. Microplastics (MPs), defined as plastic particles of less than 5 mm in size have been detected in both marine and terrestrial ecosystems worldwide, with evidence suggesting uptake by animals and accumulation along the food chain. The ethical and technological challenges associated with both in vivo and in vitro studies using human tissues, limited analytical methodologies, strict restrictions on the use of laboratory animals in toxicological studies and large variabilities associated with the allometric scaling of dermatokinetic data from animals to humans due to inter-species variability are limiting current efforts for accurate risk assessment of microplastics. By delivering more effective and sustainable alternative approaches to study the bioavailability of toxic flame-retardant chemicals (FRs), DermPlast will benefit scientists, public health and policy-makers taking informed decisions to minimize human exposure to microplastics and their toxic additive chemicals within the context of legislative frameworks such as EU REACH. This will be achieved by applying in vitro 3-dimensional human skin equivalent (3D-HSE) model to study the dermal bioavailability of toxic brominated flame retardants (BFRs) in MPs.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Dermplast is a multidisciplinary project that combines advanced environmental analytical chemistry with innovative 3D-human skin equivalent models (3D-HSE) to study the dermal absorption of toxic plastic additives (e.g. plasticizers and flame retardants) upon skin contact with microplastics (MPs) and assess the risk arising from such exposure.Recent studies have revealed direct human exposure to MPs externally and internally, confirmed by detection of MPs in human stool. However, very little is known on the extent of human exposure to MPs via different pathways and the risk it poses to human health. While there is little evidence of adverse effects associated directly with exposure to pristine MPs, there is major concern over potential toxicity from released plastic additives (e.g. plasticizers and flame retardants), many of which have been associated with serious adverse effects including cancer. The main hypothesis that Dermplast tests is that MP additive chemicals can leach out into sweat and be absorbed through human skin; thus frequent contact with MPs can lead to significant body burdens of hazardous chemicals, with consequent adverse health impacts. This will be achieved using innovative 3D-HSE cultures as sustainable, efficient alternatives to animal/human tissues. The results will be applied to develop an advanced pharmacokinetic exposure model to estimate human uptake of toxic chemicals from dermal contact with MPs and assess the risk against current exposure guidelines and toxic endpoints for these chemicals.With current research focused mainly on isolation and characterisation of MPs in different matrices (e.g. food, water and air), DermPlast will make substantial advances to the state-of-knowledge by providing novel insight into risk assessment of MPs exposure in humans. This will benefit public health and regulators by providing the essential knowledge base required to inform policies to control human exposure to MPs.

Оригинален текст от CORDIS (на английски).

Участници

THE UNIVERSITY OF BIRMINGHAM · BirminghamКоординаторОбединеното кралство