PlastiMap · Multi-dimensional mapping of the interplay between stability and plasticity in the adult visual pathway
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-09-01 → 2024-01-28
- Финансиране от ЕС
- 147 815 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Зрителната система на възрастния мозък се проучва чрез нови технологии, за да се разбере как се променя тя при различни визуални преживявания. Това помага да се разбере как мозъкът се адаптира, учи нови умения и се възстановява след наранявания.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Multi-dimensional mapping of the interplay between stability and plasticity in the adult visual pathway
Our brains are incredible organs that constantly adapt to the world around us. They strike a delicate balance between staying stable enough to work properly throughout our lives and being flexible enough to learn new things and adjust to changes. This balance is crucial for learning new skills, training our senses, and recovering from injuries or damage to our brains. We know that certain parts of our brains, like the visual system, can change in response to experiences. For example, when we lose vision or have changes in what we see, the areas of our brain that process visual information can also change. These changes are especially strong during childhood when our brains are still developing, but they can also happen in adulthood, although to a lesser extent. However, understanding exactly how and when these changes happen in the adult brain is still unknown. One reason for this is that most studies focus on small parts of the brain or individual neurons, which might not give us the whole picture. To really understand how our brains change and adapt, we need better ways to look at the whole brain and see how different brain areas interact over time. We also need methods that can give us detailed information about how neurons are working and how they change over time. By doing this, we can gain a clearer understanding of how our brains adapt and learn, both when we're young and as we grow older. In PlastiMap, we used the latest technology in brain imaging and advanced computer models to study how the visual system adapts in response to environmental changes. In particular we investigated the following research questions: Can the brain change even after it's fully developed? Is visual experience driving brain plasticity? How long does it take for brain changes to happen? Do changes in one part of the brain affect other parts too?
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Whether and how adult brains retain the ability to adapt their function and structure, especially in the context of learning, injury or restorative treatment is a fundamental question in neuroscience. In particular, understanding how neurons rewire or adapt during plasticity has been limited to (i) local electrophysiological measurements that lack the ability to report on brainwide aspects of plasticity, (ii) terminal experiments preventing longitudinal exploration in the same animal, or (iii) brainwide functional imaging with little insight into the underlying neural activity. Therefore, despite the scientific and clinical relevance of deciphering the neural substrate of neuroplasticity, a mechanistic, brain-wide study bridging the multiple spatiotemporal scales required for understanding neuroplasticity, is still lacking. We here propose to combine cutting edge functional Magnetic Resonance Imaging with calcium recordings in an animal model of visual pathway plasticity. First, we will use this exceptional multi-modal system to investigate the neurovascular coupling during visual stimulation and at-rest. Second, we will apply advanced computational neural models to characterize the functional organization of receptive fields and underlying circuitry across the rodent visual pathway and cortical layers. Third, we aim to map the time-course of functional reorganization and restructuring of neural circuitry following damage to the visual system. To do so, we will induce localized monocular retinal lesions and quantify changes in cortical organization and micro-circuitry resulting from the damage under differential visual experience (dark/ light exposure). This project will provide the first mechanistic description of adaptive circuitry processes and retinotopic (re)organization of the entire visual pathway associated with experience-dependent plasticity. Clinically, this is critical to assess the optimal timing for visual restorative and rehabilitation treatments.
Оригинален текст от CORDIS (на английски).
Участници
- FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD · LISBOAКоординаторПортугалия
Връзки
Данни: CORDIS, © Европейски съюз