REDTEAR · The Role of free Extracellular DNA in determining The Environmental Antibiotic Resistome
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-10-01 → 2023-09-30
- Финансиране от ЕС
- 183 473 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Свободната ДНК във водните екосистеми се анализира, за да се види как пренася гени за антибиотична резистентност. Разбирането на този процес помага да се ограничи разпространението на бактерии, които не се повлияват от лекарствата, и да се намалят смъртните случаи.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
The Role of free Extracellular DNA in determining The Environmental Antibiotic Resistome
The escalating emergence of antimicrobial resistance claims worldwide attention, as its anticipated consequences on human health and the global economy are projected to be as severe as those caused by cancer. Over the past few decades, morbidity and mortality linked to multiple antimicrobial resistance (AR) have significantly risen. The use of the few remaining last-resort antibiotics to treat multi-drug resistant (MDR) bacterial infections has become a common medical practice in various regions across the globe. In Europe alone, reports indicate an annual death toll of approximately 25,000 attributed to antimicrobial resistance. Thanks to the One Health concept, it is evident that an urgent response to the spread of AR requires a deeper understanding of the cycle of antimicrobial resistant bacteria (ARB). In addition to intracellular DNA (iDNA, DNA content within bacterial cells), there is another fraction known as extracellular DNA (eDNA, DNA content outside bacterial cells), which remains a potential vector for antimicrobial resistance genes (ARGs), potentially contributing to the dissemination of AR across different sectors (human, animal, environment). This underscores the need for a more comprehensive understanding of the role of eDNA in the dissemination of AR. With the REDTEAR project, we addressed this significant health and economic concern by investigating the diversity and abundance of ARGs in eDNA isolated from aquatic ecosystems. Additionally, through experimental approaches, we assessed the impact of anthropogenic pollution on the dissemination of ARGs facilitated by eDNA transformation.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Free extracellular DNA (FED) is DNA dissolved in waters and in soils, where it arrives after being excreted by livingorganisms or following the disruption of living cells. FED can be the most prominent fraction of DNA in waters subjected tostrong disturbances, where the mortality rate of microorganisms is high, e.g. wastewater treatment plants effluents. FED arecomposed by a variety of DNA fragments including resistance genes and mobile elements. There are early evidences thanFED can represent a very important, although neglected, source of antibiotic resistance genes (ARGs) in the environment,where the bacterial community can access FED and incorporate extracellular DNA by horizontal gene transfer.If this process will be confirmed and quantified by dedicated researches, our understanding of the cycle of antibioticresistances into the environment and back to human pathogens could change dramatically, calling for a whole rethinking ofthe wastewater treatments nowadays applied. The Project REDTEAR will tackle the issue and will clarify the role of FED inthe spread and the persistence of ARGs in open waters in central Europe, offering a unique opportunity for a correctmanagement of this problem, already identified as one of the major challenges for human health in the next century.
Оригинален текст от CORDIS (на английски).
Участници
- CONSIGLIO NAZIONALE DELLE RICERCHE · RomaКоординаторИталия
Връзки
Данни: CORDIS, © Европейски съюз