H2020Индивидуална стипендия2022–2023

MIC · Multi messenger Imaging of Cancer

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2022-01-01 → 2023-12-31
Финансиране от ЕС: 175 572 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Нов метод за ехография изследва ранните метаболитни и съдови признаци на рака, например при пациенти с тумори в глава и шия. Това е важно, защото сегашният ултразвук не може да открие тези промени в микромащаб.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Multi messenger Imaging of Cancer

Cancer remains the second leading cause of death worldwide according to the World Health Organization. It is a complex affliction which involves many biological processes across scales. Several imaging techniques are at a doctor's disposal in clinical practice to fight cancer. Echography, which relies on the transmission and reception of ultrasound waves, is increasingly used in to monitor cancer patients and guide therapy. Unfortunately, ultrasound is not yet capable of detecting early signs of cancer at the microscale. The aim of this research project is to develop an echography approach that enables imaging of early metabolic and vascular signs of cancer in a preclinical studies and if successful, in a pilot study in head and neck cancer patients in collaboration with Erasmus Medical Centre in Rotterdam, the Netherlands. This interdisciplinary research builds on three recent breakthroughs in the field of ultrasound: the development of high-speed 3D ultrasound imaging, the development of super-resolved ultrasound imaging of blood vessels, and the development of ultrasound biosensors capable of probing molecular environments in tissues.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Cancer remains the second leading cause of death worldwide (World Health Organization), involving various pathological processes across multiple biological scales . Ultrasound is increasingly used in clinical oncological practice for patient diagnosis, therapy guidance, and monitoring, however do not allow for imaging of the metabolic and vascular onset of cancer at the microscale . Here, I aim to develop multi-messenger ultrasound imaging for the early metabolic and vascular detection of cancer in a pre-clinical model and a pilot human head and neck oncology study. This interdisciplinary proposal will build on three recent breakthroughs in ultrasound and synthetic biology: (1) 4D ultrasound imaging at the millisecond timescale, (2) ultrasound super-resolution imaging at the microvascular scale and (3) biomolecular ultrasound imaging at the cellular scale.I will develop non-linear sound sheet imaging (NSSI) for the 3D imaging of ultrasound contrast agents regardless of their motion. Combined with localization algorithms, this method will enable 3D ultrasound microscopy (SSLM) of capillary networks perfused with clinically approved contrast agents. Using this vascular message we will characterize rat brain tumors in preclinical research. We will also evaluate the potential of the ultrasound microscopy technique to detect metastatic sentinel lymph nodes in a pilot human study. Furthermore, NSSI will be capable of imaging GVs that are small enough to extravasate the leaky vasculature of tumors. In this specific aim, I will rely on genetically engineered pH-sensing GVs developed in my host laboratory (NWO Start-up Grant STU.019.021 of the Dutch Research Council). Using this metabolic message we will detect hypoxia induced acidosis, an important biomarker of cancer. The non-invasive observation of structural and metabolic messages arising from tumors with sound, named multi-messenger ultrasound imaging of cancer (MIC), will significantly advance the potential of medica

Оригинален текст от CORDIS (на английски).

Участници

TECHNISCHE UNIVERSITEIT DELFT · DelftКоординаторНидерландия