H2020Индивидуална стипендия2021–2023

ROBOT Sensing · Reconfigurable Bio-nano Hybrid Metasurface for Biosensing

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2021-05-01 → 2023-04-30
Финансиране от ЕС: 202 681 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Нанобиосензори от хибридни материали се разработват за по-точно разпознаване на инфекциозни молекули, подобно на тестовете за COVID-19. Те ще помогнат за създаването на по-бързи и достъпни диагностични устройства, които да се използват директно на място, а не само в лаборатории.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Reconfigurable Bio-nano Hybrid Metasurface for Biosensing

In today’s world, with a growing population and increased life expectancy, there is an increasing demand for accurate identification of infectious substances affecting our health. The COVID-19 pandemic has highlighted the importance of innovation for timely and precise testing results to support proper medical interventions for individuals, public health decisions in disease control, and global health surveillance. Traditional laboratory tests have been the gold standard in detecting infectious molecular biomarkers. However, they are time-consuming, resource-intensive, and costly, hindering them from on-site point-of-care use, which is crucial for providing rapid results. Nanotechnology offers a promising solution for developing practical point-of-care nanobiosensors. Still, technical innovation and sustainability challenges persist, mainly due to the sophisticated equipment required and the high dependency on trained specialised expertise in nanodevice fabrication and utilization. It limits their potential for future practical use. In light of this, the EU-funded MSCA-IF project ‘ROBOT Sensing’ focuses on improving the reliability of nanobiosensing device fabrication. ROBOT Sensing explores new approaches from the interdisciplinary effort between biotechnology, nanotechnology, and material science. The goal is to overcome the current barriers towards sustainable device fabrication, as well as the downstream practical performance for future point-of-care diagnostics.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Our project ROBOT Sensing aims to overcome the barriers of reliable nanofabrication of bio-nano hybrid metasurface by using a safe, low-cost, straightforward, scalable method with self-assembly of DNA origami and plasmonic nanomaterials. DNA origami technique enables generation of complex plasmonic structures in micrometre-scale and serves as templates for the accurate arrangement of various nanoscale components. Unlike conventional metasurface construction building directly on the surface, multiple reconfigurable ""plasmonic switch-recognition elements"" pairs couple with lattice backbone arrays in a site-specific manner and form a well-defined reconfigurable metasurface for its practical use in nanobiosensing. During capturing a single target molecule, the plasmonic switch alters its conformation to causes change in scattering signal at polarised plasmon, resulting in dark-field scattering spectral shift under polarised light illumination, to be detected by spectroscopy or microscopic camera. Barcode pattern images generated from multiple scattering signals change in an array of switches in our metasurface supports rapid high-throughput sensing.This project creates new useful information for fundamental research on the effectiveness of the reconfigurable feature in the bio-nano hybrid metasurface in biosensing. It also matches the needs in the EU Horizon 2020 work programme on Nanotechnologies, EU One Health Action, and EU Coronavirus Response, where the evaluated biosensing ability of the nanobiosensor prototype that achieves high sensitivity, specificity, and accuracy could be translated into point-of-care multiple disease screening in disease control and surveillance. The applicant will develop complementary skills, reach professional growth and maturity through highly qualified training and activities, and contribute to the knowledge-based society, where both academic and non-academic sectors will benefit from the result dissemination and two-way communication.""

Оригинален текст от CORDIS (на английски).

Участници

AALTO KORKEAKOULUSAATIO SR · EspooКоординаторФинландия