VocalBrain · Whole-brain neural dynamics of vocal-auditory interactions in the sound-producing, transparent vertebrate Danionella translucida
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2021-09-01 → 2023-08-31
- Финансиране от ЕС
- 162 806 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Взаимодействието между слуха и гласа се проучва чрез наблюдение на мозъка на прозрачната риба Danionella cerebrum, докато тя издава звуци. Това помага да се разбере как мозъкът разгранича собствените си звуци от тези, идващи от външната среда.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Whole-brain neural dynamics of vocal-auditory interactions in the sound-producing, transparent vertebrate Danionella translucida
The auditory system can separate between external sounds and sounds that are self-generated through an animal’s movement or vocalization. While some of the mechanisms of how the brain makes this distinction are known, the current understanding is incomplete, especially how these processes play out along the auditory path – from the ear to the higher auditory processing centers in the brain. To date the only technique to study neural activity across the whole brain at a single-cell level is via light measurements, so called calcium imaging. Yet for this method to be applicable the animal model needs to be transparent for light to enter the brain and small enough to measure the whole brain under a microscope. Danionella cerebrum (DC, formerly known as Danionella translucida) is a new model in neurosciences that fulfils these criteria, as this transparent fish has the smallest known adult vertebrate brain. Additionally, DC produce audible click sounds during social communication. Therefore, the VocalBrain project aims at establishing DC as a model for whole-brain measurements of auditory-vocal interactions. Such a model will allow us to perform novel experiments and ask mechanistic questions about how the brain processes its own and external sounds.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Many animal species generate acoustic signals for social communication and are faced with the challenge to distinguish external from self-generated sounds. How does the brain accomplish this when all sounds are coming in through the ear? It requires that self- generated and external sounds are separated at some point in the central auditory system. Copies of motor commands indicate to auditory brain areas when self-generated sounds are expected to arrive. This feedforward signaling suppresses neural responses in primary auditory nuclei, as well as the auditory cortex. Neurons that are activated with self- vocalization are also found in the auditory cortex. Yet, how the signal arrives there and where along the auditory processing pathway neural encoding of self-generated and external sounds diverge, is largely unknown. These are challenging questions to address because single-cell activity needs to be recorded simultaneously across several distant brain regions. This is currently only possible with fluorescent imaging techniques, but adult vertebrate brain tissue is too opaque for large-scale optical access. Danionella translucida (DT) is a transparent, miniature fish that vocalizes in social contexts and is therefore uniquely suitable for studying whole-brain activity of auditory processing during self- vocalization. Here I propose to generate an unbiased, whole-brain map of neural activity correlated with vocal self-representation and its cancellation. For this, I will establish stimulations of fictive vocalizations in DT and combine these with auditory playback while performing whole-brain calcium imaging. This data will offer unprecedented insights into vocal-auditory interactions across a vertebrate brain.
Оригинален текст от CORDIS (на английски).
Участници
- CHARITE - UNIVERSITAETSMEDIZIN BERLIN · BerlinКоординаторГермания
Връзки
Данни: CORDIS, © Европейски съюз