HEИндивидуална стипендия2023–2026

TIME · Neuromodulation of episodic memory - how stress influences Time In MEmory and perception

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-08-01 → 2026-07-31
Финансиране от ЕС: 319 516 €
Участници: 2
Схема: HORIZON-TMA-MSCA-PF-GF

Линиите свързват координатора с партньорите.

Накратко на български

Стресът и хормонът кортизол влияят на това как възприемаме времето и как разделяме преживяванията си на отделни спомени. Разбирането на тези процеси помага да се създаде модел за влиянието на стреса върху паметта и усещането ни за време.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Neuromodulation of episodic memory - how stress influences Time In MEmory and perception

Recent European data shows that stress shortens life expectancy by 2.8 years. Critically, it also affects the way we sense and remember everyday life. TIME presents a novel approach to a fundamental question in neuroscience: how does stress affect our memory and perception of experience over time? Previous research disregarded the role of specific neuromodulators, studied stress effects selectively on a particular memory stage, and used isolated stimuli rather than complex events in naturalistic contexts. Moreover, the impact of stress on memory has never been linked to time perception during a stressful experience. TIME addresses these critical gaps with an innovative combination of cutting-edge tools: brain imaging (functional magnetic resonance, fMRI), a controlled increase of stress hormones (with pharmacological manipulations), precise measurements of sensing time (with psychophysics), and immersive virtual reality (VR) experiments. The project aims at building the first comprehensive model of stress effects on temporal memory and perception of time. The project aims to verify two hypotheses. First, we hypothesized that a stress hormone, cortisol, released in our bodies across all memory stages (encoding, consolidation, retrieval), makes it harder to separate overlapping episodes and to break our experience into coherent events (WP1, WP2). Second, we hypothesized that stress may speed up how the brain samples incoming information, which could distort our sense of time and influence how we later recall events over time (WP3). Involved mechanisms will be measured and verified at the behavioral (WP1, WP2, WP3), physiological (WP1, WP2, WP3), and neural (WP2) level. I will carry out this research at CISA, Geneva (outgoing phase) and SISSA, Trieste (return phase). Together, these world-leading centers offer a unique environment to make the project realistically achievable by bridging the gaps between neuropharmacology, neuroscience, psychophysics, and psychophysiology. TIME will move basic and applied science forward, boost my academic or non-academic career prospects.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Recent European data shows that stress shortens life expectancy by 2.8 years. Critically, it also affects the way we sense and remember everyday life. TIME presents a novel approach to a fundamental question in neuroscience: how stress affects our memory and perception of experience over time? Previous research disregarded the role of specific neuromodulators, studied stress effects selectively for a certain memory stage and used isolated stimuli rather than complex events in naturalistic contexts. Moreover, stress effects on memory have never been linked to time perception during a stressful experience. TIME addresses these critical gaps with an innovative combination of functional magnetic resonance (fMRI), a pharmacological manipulation and a novel experimental paradigm in virtual reality (VR). The project aims at building the first comprehensive model of stress effects on memory of events and perception of time. First, we hypothesize that a stress hormone cortisol released across all memory stages (encoding, consolidation, retrieval) affects our ability to separate overlapping episodes and segment our experience into events (WP1,WP2). Second, we hypothesize that a higher sampling rate of sensory input may result in a distorted sense of time and influence subsequent temporal memory (WP3). Involved mechanisms will be measured and verified at the behavioural, physiological (WP1,WP2,WP3), neural (WP2) and perceptual (WP3) level. I will carry out the research at CISA, Geneva (outgoing phase, supervised by prof. Rimmele, prof. Vuilleumier) and SISSA, Trieste (return phase, supervised by prof. Bueti), with short visits at Columbia University, NYC (prof. Davachi). Together, these world-leading centers offer a unique environment to make the project realistically achievable by bridging the gaps between neuropharmacology, neuroscience, psychophysics and psychophysiology. TIME will move basic and applied science forward, boost my academic or non-academic career prospects.

Оригинален текст от CORDIS (на английски).

Участници

SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE · TriesteКоординаторИталия
UNIVERSITE DE GENEVE · GeneveШвейцария