WAVESCOPE · Charting the sea of brain waves: Investigation of cortical traveling waves during speech processing
„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“
- Период
- 2022-06-01 → 2024-05-31
- Финансиране от ЕС
- 189 687 €
- Участници
- 1
- Схема
- HORIZON-TMA-MSCA-PF-EF
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Накратко на български
Пътуващите мозъчни вълни се анализират при обработката на реч и слухови сигнали. Разбирането на тези процеси помага за по-доброто описание на функциите на мозъка и откриването на биомаркери за разграничаване на клинични диагнози.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Charting the sea of brain waves: Investigation of cortical traveling waves during speech processing
The WAVESCOPE project aims to enhance the detection and understanding of traveling waves in neural electrophysiology data, recorded from the brain, with a focus on their role in speech and auditory processing. This research addresses the critical need to understand how neural oscillations contribute to cognitive functions. By developing advanced methodologies for detecting and analyzing traveling waves, the project seeks to provide better descriptions for the spatiotemporal dynamics of oscillations in these data, ultimately providing new insights into brain function that could inform both basic neuroscience and clinical applications. Given the increasing importance of neuroscience in addressing mental health and neurological disorders, foundational work investigating key aspects of neural data is necessary, for instance for arriving at useful biomarkers for differentiating between clinical diagnoses.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Since the beginning of the 20th century, oscillatory patterns have been identified in recordings of human brain activity. Neural oscillation research is a highly active area of investigation, with several competing hypotheses about the role oscillations might play in human cognition. Here we focus on the spatial dimension and look at the emergent topic of oscillations in the form of ‘traveling waves’. These have been detected in different cortical areas, but there is no clear computational role. In the proposed project, I will first develop the waveSCOPE toolbox for the spatiotemporal characterization of propagating events. This open source toolbox (WP1) uses a novel-to-the-research-field algorithm. The algorithm leverages the fact that we can record cortical activity with many sensors (e.g. using MEG or EEG) and arrive at multivariate estimation of phases across recording channels. This allows tracking traveling waves across many frequencies, without the selection of a prior frequency-of-interest. The procedure will be validated in resting state data and compared systematically to other state-of-the-art wave detection algorithms. I then will apply the novel methodology to speech processing data acquired via magnetoencephalography (WP2). During the processing of speech, one typically observes a complex coordinated hierarchy of rhythmic activity. We will investigate whether wave propagation direction is congruent to directions expected by functional anatomic organization and known auditory processing stages. The knowledge and skills gained from this interdisciplinary project, using a new recording modality as well as a new domain of study, will allow me to further develop a competitive scientific career as an independent researcher. In terms of scientific impact, the characterization of propagating activity will be helpful in the hunt for well-motivated abstractions in the amount of ever-increasing brain data and therefore of fundamental importance for neuroscience.
Оригинален текст от CORDIS (на английски).
Участници
- ERNST STRUNGMANN INSTITUTE GGMBH · Frankfurt Am MainКоординаторГермания
Връзки
Данни: CORDIS, © Европейски съюз