HEИндивидуална стипендия2023–2026

MANGO · The chemical exposoMe of pregnAnt womeN with GestatiOnal diabetes mellitus

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-04-01 → 2026-03-31
Финансиране от ЕС: 261 381 €
Участници: 3
Схема: HORIZON-TMA-MSCA-PF-GF

Линиите свързват координатора с партньорите.

Накратко на български

Химичните вещества в околната среда и тяхното влияние върху бременни жени с гестационен диабет се анализират чрез биологични проби. Това помага да се разбере как тези вещества повишават риска от заболяването и да се създадат политики за превенция.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

The chemical exposoMe of pregnAnt womeN with GestatiOnal diabetes mellitus

The MANGO project is rooted in the understanding that environmental chemical exposures contribute significantly to chronic disease development, especially in vulnerable populations like pregnant women. In today’s world, individuals are exposed to a complex array of chemicals—both low concentrations of high-toxicity chemicals and high levels of those considered lower in toxicity. This layered exposure scenario has driven the European Commission to prioritize reducing hazardous chemical exposure, reflected in initiatives like the HBM4EU or PARC and SDG3 for Good Health and Well-being. To address the intricate nature of these exposures, the concept of the exposome—defined as the totality of an individual’s environmental exposures from conception onwards—has emerged as a critical framework. The exposome encompasses the wide variety of chemical exposures and their potential interactions over time, offering a comprehensive approach to understand how these factors collectively influence health. MANGO applies this exposomic perspective to capture a broad, untargeted profile of chemical exposures specific to the maternal-fetal window, which is known to be particularly sensitive to environmental influences. MANGO’s primary objective is to conduct an exposome-wide analysis to identify chemical exposures that may elevate the risk of Gestational Diabetes Mellitus (GDM). Leveraging biological samples from the “Diabetes and Pregnancy” (DaP) cohort at IISPV/Hospital Joan XXIII, this project utilizes advanced analytical chemistry tools and statistical models to chart the unique exposomic signatures associated with GDM. In doing so, MANGO aims to establish a robust evidence base for chemical exposure-related health policies and develop a targeted pilot program for exposure prevention during pregnancy. This program will offer actionable recommendations to reduce hazardous exposures, contributing both to maternal-fetal health and broader regulatory frameworks across Europe.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

There is a lack of knowledge on the multitude of chemicals that we are exposed to, and even less is known about the exposure during pregnancy, the most critical window for adverse health effects on both mother and offspring. In turn, the prevalence of Gestational Diabetes Mellitus (GDM) has incredibly increased during the last decades and it is now diagnosed in up to 18% of the pregnancies. In this context, I propose the project “The Chemical Exposome of Pregnant Women with Gestational Diabetes Mellitus (MANGO)” to be co-supervised by Dr. Navas-Acien and Prof. Gary Miller at Columbia Mailman School of Public Health (USA, Third Country for the outgoing phase), and by Prof. Domingo at Universitat Rovira i Virgili (URV, Spain, beneficiary institution and host for the incoming phase). The main scientific goals of MANGO are: (1) to determine the occurrence of non-target chemicals in biological samples of 400 pregnant women; (2) to evaluate the association between the exposure to chemicals and clinical data, exploring the effect modification by sociodemographic, dietary and lifestyle factors; (3) to implement a pilot prevention programme to minimize the exposure to hazardous chemicals during pregnancy. These objectives will be tackled by integrating last advances in high-resolution mass spectrometry (WP1), mathematical models (WP2) and risk assessment and prevention strategies (WP3). MANGO will leverage biological samples of Diabetes and Pregnancy Cohort from Institut d’Investigació Sanitària Pere Virgili/Hospital Universitari Joan XXIII (IISPV/HJXXIII, associated partner) and will return the knowledge to Europe by implementing the first pilot programme to increase the awareness of the exposure to hazardous chemicals. Through this MSCA-PF-GF, my training in environmental epidemiology in USA would capitalize upon my skills on non-target chemical analysis (MSCA cofund in INSULIN Tecniospring), facilitating the start of a new research line and a track-tenure at URV

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITAT ROVIRA I VIRGILI · TarragonaКоординаторИспания
FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) · TarragonaИспания
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK · New YorkСъединени щати