HEИндивидуална стипендия2022–2024

PACMAN · sPatially and environmentAlly aCtuable nancoMposite hydrogels towArds Nervous system repair

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2022-07-01 → 2024-06-30
Финансиране от ЕС: 172 750 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Нанокомпозитните хидрогели се разработват като структури от различни размери, които да помагат при възстановяването на нервната система. Тези материали позволяват по-добро контролиране на освобождаването на вещества и проникването на клетки, което може да подобри резултатите в тъканното инженерство.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

sPatially and environmentAlly aCtuable nancoMposite hydrogels towArds Nervous system repair

The overall objective of the project is to develop nanocomposite hydrogels with the potential to improve outcomes in nervous system repair. In order to accomplish this objective, a multidisciplinary project was undertaken in order to fabricate multifunctional, nanocomposite hydrogels. These were created by engineering across length scales- from the nanoscale (mesoporous silica nanoparticles) to the microscale (polyethylene (PEG) microgels) and up to the macroscale (granular hydrogel scaffolds). The ability to engineer scaffolds across length scales increases the potential to create multifunctional scaffolds. Therefore, PACMAN sought to develop nanocomposite hydrogels that have engineered degradation, payload release, mechanical properties, porosity, and cellular infiltration properties. Due to the many applications of hydrogels in tissue engineering, the results of PACMAN have the potential to be exploited across many areas of tissue engineering beyond just nervous system repair.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This proposal aims to capitalize on my unique multi-disciplinary expertise in nanotechnology, tissue engineering, polymer/inorganic hybrids, and microsurgical techniques, while acquiring new proficiencies in the creation of breakable hybrid organosilica nanocapsules, mesoporous silica nanoparticles, and nanocomposite hydrogels. I am driven to tackle the unmet needs, opportunities, and challenges in the fields of nanocomposite hydrogel design and nervous system repair by combing my current expertise with these new proficiencies to innovate nanocomposite hydrogels that are environmentally and spatially actuable. Specifically, the goal of my proposal is to pioneer spatially distinct and environmentally responsive actuation of nanocomposite hydrogels in response to matrix metalloproteinase-9 (MMP-9) peptide cleavage, focusing on applications in peripheral nerve repair. In order to achieve this ambitious objective, I will develop MMP-9 degradable polyethylene glycol (PEG)/mesoporous silica nanoparticle composites and MMP-9 breakable organosilica nanocapsules through the incorporation of MMP-9 cleavable peptides into silica nanoparticle structures. MMP-9 can therefore be used to induce: 1) hydrogel degradation, 2) release of encapsulated therapeutics, and 3) capture of molecules by cleaved nanoparticle scavengers. This proposal details a highly interdisciplinary approach to create a plug-and-play nanocomposite hydrogel system to overcome obstacles needed to improve regeneration outcomes by combining neuroscience and microsurgical nerve repair with chemistry, drug delivery, biomaterials science, and tissue engineering. Finally, nanocomposite nerve guidance conduits will be tested in a peripheral nerve injury model to demonstrate in vivo MMP-9 actuation of these hydrogels.

Оригинален текст от CORDIS (на английски).

Участници

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI · MILANOКоординаторИталия