HEИндивидуална стипендия2022–2024

SynEMO · Synaptic dendritic architecture as a determinant for processing emotional information of opposite value in amygdalar-hippocampal subnetworks

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2022-10-01 → 2024-09-30
Финансиране от ЕС: 172 750 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Синаптичните връзки в мозъка определят как се обработват положителните и отрицателните емоционални спомени. Разбирането на тази организация помага за създаването на модели, които могат да подобрят терапията при тревожност и депресия.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Synaptic dendritic architecture as a determinant for processing emotional information of opposite value in amygdalar-hippocampal subnetworks

Survival depends on the ability to form emotional memories by associating environmental cues with rewarding or aversive stimuli. A critical brain structure in this process is the basolateral amygdala (BLA), where distinct populations of neurons encode positive and negative stimuli. By project to the ventral CA1 region of the hippocampus (vCA1), forming pathways that route information of opposite valence. The specific mechanisms by which these pathways enable vCA1 neurons to process distinct emotional information remain poorly understood. The SynEMO project investigated how synaptic inputs from the BLA, CA3 pyramidal neurons, and bistratified interneurons (BiS-INs) converge on vCA1 dendrites and contributes to emotional learning and memory. The project provides a framework that addresses how the spatial organization and clustering of synaptic inputs at the dendritic level influence circuit activity. This is a highly relevant question, expected to enrich the understanding of information processing, by providing a generalizable model that considers synaptic arrangements. SynEMO’s findings advance the development of detailed neuronal models, enriching basic neuroscience research. In addition, such models offer significant implications for addressing mental health disorders such as anxiety and depression, providing a foundation for novel therapeutic strategies.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The ability to form emotional memories of aversive or rewarding stimuli is a crucial ability to determine avoidance or approaching behavior. Recent reports identify specific populations of nThe ability to form emotional memories of aversive or rewarding stimuli is a crucial ability to determine avoidance or approaching behavior. Recent reports identify specific populations of neurons within the basal and lateral nucleus of the amygdala (BLA) and their corresponding projections that are selectively activated during the retrieval of memories of positive or negative valence. Interestingly, BLA neurons projecting to the CA1 area of ventral hippocampus (vCA1) are tuned for either positive or negative predicting cues, suggesting the existence of two distinct pathways routing opposite information to vCA1. How emotional values originating from the BLA are differentially processed by downstream vCA1 neurons remains unclear. An appealing possibility is that vCA1 encodes different valence-related information through distinct spiking patterns and temporal structures. Distinct signal processing in the two BLA-vCA1 pathways might be supported by specific non-linear dendritic input integration, a mechanism that can be promoted by input clustering induced by heterosynaptic plasticity. We hypothesized that an organized synaptic distribution within BLA-vCA1 subnetworks exists, and that local heterosynaptic plasticity determines different temporal structures of neuronal output vCA1 in the processing of negative or positive information. We will use a novel viral-based tracing approach combined with an established assembly-labeling strategy to understand the anatomical input-specific structural organization synapses of different valence-related information along vCA1 dendritic arbour. Then, to dissect the functional implication of such synaptic organization, we will employ a combination of single-spine calcium imaging, electrophysiology, behaviour and in vivo endoscopic calcium imaging.

Оригинален текст от CORDIS (на английски).

Участници

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA · GenovaКоординаторИталия