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HEИндивидуална стипендия2022–2024

FLEXNEUROCOMP · Neural computations and dynamics of flexible decision-making in mice

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2022-09-01 → 2024-12-31
Финансиране от ЕС
168 621 €
Участници
3
Схема
HORIZON-TMA-MSCA-PF-EF

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Накратко на български

Механизмите за вземане на решения при мишките се проучват чрез наблюдение как те избират различни стратегии за търсене на храна. Това помага да се разбере как премоторната кора в мозъка планира действията и управлява гъвкавостта на поведението.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Neural computations and dynamics of flexible decision-making in mice

The FLEXNEUROCOMP project explored how mice make decisions while searching for food. We wanted to understand how their brains flexibly choose between different approaches, both in terms of their actions and the brain activity involved. We used complex tasks where mice could use multiple strategies to find food, coupled with cutting-edge technology to record and influence the activity of many brain cells at once, across different brain areas. A key focus was the area of the mouse brain called the "premotor cortex," which is thought to be involved in planning actions. We wanted to see if this region holds a "library" of different decision-making strategies and directs which one gets used for a given situation, ultimately influencing the mouse's actions.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Imagine that you have just rung at a doorbell and no one has answered the door. Is there anybody home? How many times should you ring? One simple solution is just to ring several more times and wait. Yet, to save time and make sure that no one is home, you could also consider whether there is a light inside the house or whether there is a car parked in front. Although such situations are ubiquitous in our daily life, relatively little is known about how different decisions are implemented in the brain and how they flexibly inform behavior. This proposal directly aims to characterize decision variables both at the behavioral and neural levels to understand how the brain flexibly switches between them. We will combine sophisticated mice behaviors that accommodate multiple decision variables with innovative models of dynamical systems, and leverage the latest progress in electrophysiology and optogenetics to record and manipulate large ensembles of neurons simultaneously across multiple brain regions. This work will test the overarching hypothesis that the premotor cortex, thought to implement the intention to act, is a reservoir of decision variables that flexibly routes the employed decision variable to motor regions. Our highly multidisciplinary team, which consists of the researcher with productive records in systems neuroscience, the supervisor who is a specialist in cognitive neuropsychology, and the secondment supervisor who is a renowned theoretical neuroscientist, is well armed to successfully carry this project. Our results should deliver a new conceptual framework for understanding adaptive behaviors and their neural bases. This project will also provide a direct window into the neural mechanisms underlying individual variations in decision making and how actions may depart from a healthy behavior when erroneous or maladaptive strategies are used, of relevance for explaining diversity in human behavior and mental health.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз