HEИндивидуална стипендия2022–2024

DEAR-Waste · Dynamics of communities and Evolution of Antibiotic Resistance in Wastewater

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2022-09-01 → 2024-08-31
Финансиране от ЕС: 181 153 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Бактериалните общности в градските канали се изследват, за да се разбере как остатъците от антибиотици влияят върху развитието на резистентност. Това помага за по-доброто управление на антибактериалната устойчивост, за да се защити здравето на хората и животните.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Dynamics of communities and Evolution of Antibiotic Resistance in Wastewater

Environmental antibiotic resistance poses a significant threat to both human and veterinary health, making it a central focus of the European One Health Action Plan Against Antimicrobial Resistance. Urban sewers, rich in diverse bacterial communities, are constantly exposed to antibiotic residues from human waste. This exposure creates a reservoir of antibiotic-resistant bacteria. To predict the evolution of antibiotic resistance in these environments, it is essential to understand the dynamics of wastewater bacterial communities exposed to antibiotics. However, the complexity of sewer environments, which contain multiple interacting abiotic factors, complicates such predictions. These factors may interact in non-additive ways, further influencing the evolutionary landscape. Additionally, interactions between bacterial species within the sewer microbiome affect growth and competition, operating through both density- and frequency-dependent processes. These interspecies interactions can alter the competitive fitness of antibiotic-resistant strains, thereby influencing evolutionary outcomes. The DEAR-Waste project seeks to unravel these complexities by studying the dynamics of bacterial communities and antibiotic resistance evolution in urban sewers. The project also aims to establish wastewater as a valuable model system for fundamental research on community dynamics and microbial evolution. By exploring how diverse factors within sewers interact to drive resistance, DEAR-Waste contribute valuable insights for managing antibiotic resistance, ultimately supporting efforts to protect public and veterinary health.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Environmental antibiotic resistance is a major threat to human and veterinary health and a key issue addressed by the European One Health Action Plan Against Antimicrobial Resistance. City sewers shelter rich and diverse bacterial communities that are continuously exposed to antibiotic residues from human excreta, thus becoming a reservoir of resistance. Predicting the risk of antibiotic resistance evolution in city sewers requires a comprehensive understanding of the dynamics and evolution of wastewater bacterial communities faced to such exposition. However, sewers are complex environments and contain multiple abiotic factors, which may act in non-additive ways. In addition, interactions between species within communities affect growth and consequently competition, through both density- and frequency-dependent processes. By changing the competitive ability of variants, such as antibiotic resistant phenotypes, interspecies interactions also change evolutionary processes.DEAR-Waste aims at understanding the dynamics of communities and antibiotic resistance evolution in city sewers, together with establishing wastewater as a model system for fundamental studies on community dynamics and evolution. DEAR-Waste adopts an interdisciplinary approach, combining high-throughput sequencing technologies, environmental chemistry, microbial ecology and evolution, time-series statistical analysis, and formal modelling. Data from synthetic mesocosms will parametrize the Hutchinsonian niche for population in communities: a tolerance curve mapping species performance onto a complex environmental space defined by the multidimensional abiotic environment and species interactions. Predictions from these curves will be tested against field measurements of microbial and chemical dynamics sampled in city sewers. An evolutionary experiment in similar mesocosms will finally quantify how environmental complexity and interspecies interactions modulate the evolution of antibiotic resistance.

Оригинален текст от CORDIS (на английски).

Участници

FUNDACIO INSTITUT CATALA DE RECERCA DE L'AIGUA · GironaКоординаторИспания