HEИндивидуална стипендия2022–2024

VISIBLE · Virus-host interactions in the Baltic Sea

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2022-12-01 → 2024-11-30
Финансиране от ЕС: 222 728 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Взаимоотношенията между вирусите и техните бактериални гостоприемници в Балтийско море се анализират чрез генетични данни. Това помага да се разбере как вирусите контролират микробите и влияят върху здравето на водната екосистема.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Virus-host interactions in the Baltic Sea

Microorganisms are essential to aquatic ecosystems. They are the most numerous and diverse organisms, playing a vital role in maintaining ecosystem health. These tiny organisms support food webs, drive half of the world's primary production, and help clean up pollution. Viruses kill a large number of aquatic microorganisms daily but this process contributes to ecosystem function. Viral lysis releases organic matter for other microbes to consume and has also been implicated in the termination of toxic algal blooms. During infection, viruses can also alter their hosts' metabolism, contributing to primary production and biogeochemical cycles. Viruses can thus shape the structure and function of aquatic microbial communities. Bacteria and viruses coexist in aquatic environments in complex ways, which can be studied through metagenomics (DNA sequenced directly from the environment). With this approach, it is possible to recover the genomes of both bacteria and viruses. A key challenge is linking viruses to their specific hosts. Funded by the European Union, the VISIBLE project (VIrus-hoSt Interactions in the BaLtic SeA) examined long-term microbial and viral data from the Baltic Sea to uncover virus-host relationships and their role in the ecosystem.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Dr. Bell proposes to work with Prof. Andersson at KTH Royal Institute of Technology, Sweden, to study VIrus-hoSt Interactions in the BaLtic sEa (VISIBLE). Bacteriophages (bacteria specific viruses) are the most abundant biological entity on the planet, yet we are only beginning to grasp the impact they have upon ecosystem functioning. Using state-of-the-art metagenomics, viromics and bioinformatics, the fellow will uncover novel genomes of virus populations in the Baltic Sea and the prokaryotic hosts they infect. Multiple approaches (abundance, CRISPR spacer matching and homology of auxiliary metabolic genes) will be combined to uncover virus-host dynamics. The metagenomic and viromic dataset has a high temporal resolution spanning a three-year period making it possible to answer fundamental ecological questions: (1) How are the temporal dynamics of viruses related to that of their hosts? (2) Can the co-evolution of viruses and their hosts be detected? (3) Do the function of auxiliary metabolic genes reflect changes in environmental gradients? These questions have major implications for biogeochemical cycling and resource turnover in the marine biosphere, as well as water resource management and predicting ecological responses to climate change. By means of a multidisciplinary approach, the fellow will advance their current research skills in microbial ecology and bioinformatics and gain new skills in virology. The MCSA fellow will join a world-class host institute and world-leading research team in environmental genomics. They will establish new interdisciplinary collaborations with researchers from across Sweden and Europe and develop their communication, management and leadership skills. KTH has been awarded HR Excellence in Research and supports the MCSA Green Charter. KTH provides the ideal environment and infrastructure for the fellow to carry out this research and to develop as a leading independent researcher.

Оригинален текст от CORDIS (на английски).

Участници

KUNGLIGA TEKNISKA HOEGSKOLAN · StockholmКоординаторШвеция