HEИндивидуална стипендия2023–2024

AnBioLED · AnBioLED Ancestral Fluorescent Proteins as Biophosphors for Light-Emitting Diodes

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-01-01 → 2024-12-31
Финансиране от ЕС: 173 847 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Древни флуоресцентни протеини се тестват като биолуминофори в LED лампите, за да заменят токсични материали като кадмия. Това помага за създаването на по-стабилни и биоразградими технологии за осветление, които да бъдат конкурентни на пазара.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

AnBioLED Ancestral Fluorescent Proteins as Biophosphors for Light-Emitting Diodes

Sustainable light technologies are overcoming certain challenges in order to become attractive enough to compete with market options. One of such challenges is the replacement of toxic or rear-Earth materials like cadmium or cerium as color downconverters in Light Emitting Diodes (LEDs). The usage of Fluorescent Proteins (FPs) is a novel sustainable approach, leading to the development of Bio-Hybrid LEDs (Bio-HLEDs). However, a second challenge to overcome is the device stability in Bio-HLEDs. Since FPs are not biologically adapted to be used as a technological component in light devices, the project AnBioLED (Ancestral fluorescent proteins as Biophosphors for Light-Emitting Diodes) aimed to estimate ancestral-like FPs out of the sequences of present day FPs. This was made under the premise that ancestral sequence reconstruction tends to give place to proteins that are more resistant to certain stresses than present day FPs. During the AnBioLED project, ancestral-like FPs with exceptionally efficient color emission and better stability than previous FPs used so far in Bio-HLEDs have been discovered. The expected impacts of this project are: 1) the development of LEDs with biodegradable ancestral-like FPs as color downconverters that can compete with previous state-of-the-art in terms of color emission and stability and 2) the usage of ancestral-like FPs as scaffolds to engineer a novel family of proteins for technological applications.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Light Emitting Diodes (LEDs) are present in displays of the great majority of devices we use every day, including smartphones, computers, TVs, etc. Unfortunately, they use toxic non-renewable rare-earth materials for their functioning. Fluorescent Proteins (FPs) have already proven to be an eco-friendly alternative, but their performance over time decreases as the intensity of the excitation source increases. This is because FPs have not been naturally or artificially evolved to function as color converters in electronic devices. Since it is not possible to artificially evolve proteins under LED operation conditions (stress), AnBioLED proposes to merge through machine learning evolutionary information (Ancestral Sequence Reconstruction) and computational protein design to identify key mutations in order to improve FPs photo and thermal stability. More importantly, AnBioLED will use experimental results under device operation conditions to reinforce the protein design strategy. The new ancestral FPs will merge the excellent photoluminescence properties of existing FPs with the robustness of their ancestors. AnBioLED novel approach will allow for the first time to optimize existing FPs for LEDs applications.

Оригинален текст от CORDIS (на английски).

Участници

TECHNISCHE UNIVERSITAET MUENCHEN · MuenchenКоординаторГермания