HEИндивидуална стипендия2023–2024

SusIsocyanide · A New Light on Isocyanide Synthesis

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-01-01 → 2024-12-31
Финансиране от ЕС: 189 142 €
Участници: 2
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Изоцианидите са химични съединения, използвани за създаване на антибактериални и противомаларийни лекарства. Нови методи за тяхното производство чрез видима светлина и биомаса ще направят процеса по-екологичен и достъпен за индустрията.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

A New Light on Isocyanide Synthesis

Isocyanides are highly versatile building blocks in organic chemistry, with significant applications in material science and the pharmaceutical industry. Many isocyanide-containing molecules, such as xanthocillin and stilbene isocyanides, exhibit potent antibacterial, antifungal, and antimalarial properties. However, the commercial availability of isocyanides remains constrained by the absence of efficient and sustainable catalytic methods for their large-scale production. This limitation creates a bottleneck in meeting the growing demand for these valuable compounds. The SusIsocyanide project addresses this pressing need by pioneering new methodologies for the scalable and eco-friendly synthesis of isocyanides. Central to this effort is the use of photoflow reactors, which harness visible light as a renewable energy source. By integrating bio-based scaffolds, the project aims to achieve enhanced efficiency and sustainability in isocyanide production. The project's outcomes are expected to have a transformative impact on both scientific innovation and societal needs. By utilizing non-toxic chemicals and renewable resources, SusIsocyanide seeks to minimize environmental impact, enable cost-effective large-scale production, and enhance the accessibility of isocyanides. These advances will support their broader application across industries, offering significant benefits in healthcare, materials development, and beyond.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

SusIsocyanide is an ambitious project that aims for the sustainable synthesis of isocyanides by combining biobased feedstock, visible light and flow chemistry. The aim is to accomplish an economically viable and ecofriendly large scale synthesis of this fundamental and highly versatile building block that has already found widespread appreciation in academia, but suffers from underutilization in the pharma-, fine-chemicals and materials industry. In accordance to the European Green Deal, the devised methodologies will provide an expedient synthetic platform to achieve the automatic synthesis of isocyanides, without the need of toxic and hazardous reagents and avoiding substantial waste production. This will constitute a ground-breaking improvement far beyond the current state-of-the-art, especially considering that the traditionally employed synthetic procedures towards isocyanides have hindered large-scale preparation and therefore industrial utilization. In light of the main goal, SusIsocyanide will constitute a launching platform for the Fellow, since the interconnection between his expertise in photoredox catalysis and flow chemistry and the experience of the host group (Maastricht University) in isocyanide chemistry provides fertile soil for fruitful collaboration and success. Because of the close collaboration in this project with Brightland Chemelot Campus, the Fellow is trained in the industrial utilization of isocyanides in polymer synthesis and advance functional material applications. This highly complements his academic knowledge with industrial application of the developed ideas.Overall, SusIsocyanide will provide a sustainable alternative for the synthesis of isocyanides, taking into account further implementation through industrial applications. The use of simple green feedstock in combination with enabling technologies is the key element that makes the difference to achieve the overall aim and objectives presented.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITEIT MAASTRICHT · MaastrichtКоординаторНидерландия
UNIVERSITAET REGENSBURG · RegensburgГермания