Меню
КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
HEДокторантска мрежа2023–2027

FC-RELAX · NMR relaxometry for biomedicine and advanced materials

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2023-03-01 → 2027-02-28
Финансиране от ЕС
2 601 108 €
Участници
13
Схема
HORIZON-TMA-MSCA-DN

Линиите свързват координатора с партньорите.

Накратко на български

Методът на полево-циклиращата релаксометрия анализира молекулярната структура и динамика, например при създаването на по-безопасни контрастни вещества за ЯМР. Това помага за по-доброто разбиране на молекулярните функции и подобрява работата на устройствата за съхранение на енергия.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

NMR relaxometry for biomedicine and advanced materials

The main aim of this multidisciplinary doctoral network is to train a new generation of scientists with outstanding knowledge in the field of field-cycling relaxometry. Field-cycling relaxometry is a versatile tool allowing for the investigation of molecular structure and dynamics on a wide time scale, from picoseconds to milliseconds. This technique provides information which are key in several biomedical applications, as well as in the characterization of advanced materials, thus with a great potential of impact. The knowledge of the molecular dynamics, together with that of the structure, is of central importance to fully understand the mechanisms underlying molecular functions, and field-cycling relaxometry is one of the very few techniques which can provide information on motions occurring on time scales longer than nanoseconds. In this frame, the fellows are trained to acquire a deep knowledge of the different, possible applications of the technique, ranging from molecular biology and inorganic chemistry to biophysical methods. In addition, they are trained to the mastery of theoretical tools, with a multi-disciplinary integrative view made possible by the different expertise of the consortium partners. A multisectoral training is ensured by the presence in the network of 3 industrial partners and 10 academic partners and by the scheme of planned secondments. The projects of the recruited DCs focus on different research fields and/or on technological and theoretical developments: - the improvement of efficacy and safety of magnetic resonance imaging contrast agents and paramagnetic nanosystems for theranostics - the development of partially crystalline materials and of ionic liquids for their use as electrolytes in energy storage devices - the exploitation of relaxometry for cancer diagnosis - the development of the theoretical knowledge of field dependent relaxation processes to unravel dynamic processes occurring in complex systems. The project thus contributes to a better understanding of key molecular processes occurring in biological systems and in materials to unlock innovations in biomedical technology, medical diagnosis, ionic liquids for energy storage, design of innovative drugs and biologics acting on specific molecular targets. These scientific achievements may thus open new routes for early detection of diseases by improving the diagnostic methods heavily relying on the efficiency of magnetic resonance imaging (MRI), and to the optimal exploitation of electrolytes, key devices for large-scale energy storage systems.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Field-cycling relaxometry experienced a tremendous boost during the last decade. It represents an ease and versatile tool to monitor structure and dynamics in a wide range of time scales, from picoseconds to milliseconds, providing information of great importance for understanding the properties of biological systems and improving materials and drugs. Despite the numerous, emerging possibilities of applications, theoretical approaches for the analysis of the relaxometry data are often controversial and, for some systems, accurate models have not been identified. The FC-RELAX project aims at developing the theoretical knowledge of the field dependent relaxation processes taking advantage of the joint effort of some of the main European actors in the field, and at exploiting all potentialities of field-cycling relaxometry for different biomedical applications and for the characterization of advanced materials. The objectives are the improvement of efficacy and safety of MRI contrast agents and paramagnetic nanosystems for theranostics, the exploitation of relaxometry for cancer diagnosis and for the development of partially crystalline materials, and of ionic liquids for their use as electrolytes in energy storage devices. The program is based on high-level multidisciplinary and multisectoral training, and on a consortium of tight and complementary experimental scientists and theoreticians. FC-RELAX comprises 10 academic partners and 3 companies from 8 European countries, and will train 10 researchers who will benefit by extensive interactions between academic and industrial partners, endowed with state-of-the art scientific and technical expertise and infrastructures. The industrial partners include the only company in the world producing field-cycling relaxometers, a European company leader in the research and production of MRI contrast agents, and a scientific oriented technology company on the world market of magnetic resonance instrumentation.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз