HEИндивидуална стипендия2023–2024

RegionalDopamine · Parsing dopamine's learning and motor functions

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-01-01 → 2024-12-31
Финансиране от ЕС: 187 624 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Допаминът в определена част от мозъка се изследва, за да се разбере дали той управлява само движението или и начина, по който се учим чрез награди. Това помага за разбирането на затрудненията при хора с болест на Паркинсон.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Parsing dopamine's learning and motor functions

Appropriate selection of situation-appropriate behavior in our everyday life requires both learning and motor control. A key neuromodulator involved in these processes is dopamine, particularly in the basal ganglia. Here, dopamine is thought to reflect the difference between an expected and obtained outcome, also referred to as a reward-prediction error signal. On the other hand, dopamine is vital for movement, making it difficult to disentangle its role in learning and from its role in action control. The overlap is especially apparent in disorders such as Parkinson’s disease, which is characterized by the degeneration of dopaminergic neurons. People with Parkinson’s disease often exhibit difficulty initiating or suppressing movements and learning through rewards. Our project investigates how dopamine in the ventromedial striatum (VMS) contributes to both reward processing and movement. The goal is to clarify how dopamine supports behavior, by identifying whether its signals are driven by the reward itself or by the actions taken to obtain it or both.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Appropriate selection of situation-appropriate behaviour requires both learning and motor control. Release of the neurotransmitter dopamine in the striatam is crucially involved in both of these processes. However, previous work investigated learning and motor functions of dopamine in isolation. To fully understand dopamine function and dysfunction, it is imperative to take both learning and motor control into account. Striatal dopamine release is thought to encode a reward prediction error, the discrepancy between expected and obtained outcome, as well as promote movement. Dopamine release optimises and drives behaviour by modulating the activity of striatal medium spiny neurons (MSNs) and their downstream neural pathways. Binding of dopamine to type-1 and type-2 dopamine receptor-expressing MSNs differentially modulate intracellular signalling cascades, increasing or decreasing phosphorylation of protein kinase A (PKA), respectively. Differential modulation of PKA activity is thought to underlie learning and motor control, ultimately driving behaviour. Importantly, dopamines influence on MSNs is functionally disparate between limbic, associative, and sensorimotor domains, and it is hypothesised that these regions differentially encode learning and movement. Here, I aim to discern the entanglement of dopamine functions by employing a powerful behavioural task that differentiates between learning and movement, while 1) simultaneously recording dopamine release in distinct striatal domains, and 2) recording the activity type-1 or type-2 MSNs using a novel, cutting-edge tool to detect real-time PKA activity. The complementary power of these innovations will enable me to drive forward the current understanding of dopamines function by combining state-of-the-art neuroscience techniques, elucidating the entanglement of dopamine in learning and motor control on behaviour.

Оригинален текст от CORDIS (на английски).

Участници

STICHTING AMSTERDAM UMC · AmsterdamКоординаторНидерландия