HEИндивидуална стипендия2022–2024

SESAHME · Spatially rEsolved Single-cell Approaches in Haematologic MalignanciEs

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2022-09-01 → 2024-08-31
Финансиране от ЕС: 173 847 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Костният мозък и взаимодействието между раковите клетки и средата около тях се анализират при множествен миелом. Това помага за разбирането на това как микросредата влияе върху развитието на болестта и отговора на пациентите към имунотерапията.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Spatially rEsolved Single-cell Approaches in Haematologic MalignanciEs

Bone marrow is the soft tissue that fills bone cavities and constitutes the primary site of blood cell production. However, it is also one of the most complex niches in which cancerous cells accumulate. Multiple myeloma, the second most common blood cancer, is a paradigm of a tumor in which malignant plasma cells interact with a bone marrow microenvironment. Additionally, novel immunotherapeutic strategies, that target multiple myeloma cells in a complex interplay with immune cells in their microenvironment, highly depend on the bone marrow microenvironment composition. Accordingly, understanding the immunomodulating effects of drugs and the patient-specific contributions of the bone marrow microenvironment to therapy response are emerging as critical aspects for advancing treatment. However, our current understanding of bone marrow microenvironment heterogeneity and dynamics in multiple myeloma is limited. Risk stratification models and treatment strategies are primarily based on tumor genetics and clinical factors. They fail to fully account for the influence of the bone marrow microenvironment on disease progression and treatment response. SESAHME addresses this gap by comprehensively mapping a healthy and dysfunctional bone marrow microenvironment that can contribute to cancer development or promote disease progression and drug resistance. This could lead to advanced immunotherapy approaches in the future.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

A global understanding of therapy response and therapy resistance in haematologic malignancies, including multiple myeloma and acute lymphoblastic leukaemia, in which cancerous cells accumulate in the bone marrow, is still lacking. This is due to the complex nature of the bone marrow. Therefore, the goal of SESAHME is to determine the difference of the bone marrow microenvironment in healthy individuals and patients suffering from multiple myeloma and acute lymphoblastic leukaemia. This will help to understand under which conditions cancerous cells can accumulate and proliferate in the bone marrow which could lead to advanced immunotherapy approaches in the future.To achieve this, the objectives of SESAHME are to 1) establish a method that allows to determine the immune microenvironment composition in human formalin-fixed paraffin-embedded samples of the bone marrow, which has the potential for high-throughput screening and being cost effective at the same time; and 2) to use this method to characterise a healthy and dysfunctional bone marrow microenvironment that can contribute to multiple myeloma/acute lymphoblastic leukaemia development and progression.SESAHME will allow the fellow to independently carry out a project which will set the ground to build upon an own, individual research profile to eventually become an independent researcher. Key transferable training will further improve the employability and career prospects of the fellow, as well as increase the fellow’s communication abilities. The host offers a multi-disciplinary environment that is well connected with experts in the field enabling the fellow to develop a new mindset and approaches. The fellow brings international and specialised wet-lab experience that will facilitate knowledge exchange and increase R&I capacity. Finally, SESAHME will increase the global attractiveness of the host via concrete dissemination activities.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITATSKLINIKUM HEIDELBERG · HeidelbergКоординаторГермания