HEИндивидуална стипендия2022–2024

SUPREME · Polymeric Cyclodextrin-Based Supramolecular Constructs Photoreleasing Nitric Oxide for Combating Antibiotic Resistance

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2022-08-01 → 2024-11-30
Финансиране от ЕС: 172 750 €
Участници: 3
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Специални полимерни структури се използват за доставяне на азотен оксид и антибиотици, които се активират чрез видима светлина. Това помага за справяне с бактериите, които са развили устойчивост към стандартните лекарства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Polymeric Cyclodextrin-Based Supramolecular Constructs Photoreleasing Nitric Oxide for Combating Antibiotic Resistance

Multidrug resistance (MDR) in bacteria is the prime example of bacterial adaptation and the pinnacle of evolution and remains the greatest challenge in public health care. The World Health Organization has named antibiotic MDR as one of the three most important public health threats of the 21st century and the EU has recognized and included in the Action Plan against the rising threats from antimicrobial resistance, “Infectious diseases represent a very significant burden for developing nations”. The slogan of one of the latest World Health Day was “Antimicrobial resistance: no action today no cure tomorrow.” This scenario, associated to the low turnover of new clinically approved antibiotic drugs, makes the development of novel therapeutic approaches to fight antibiotic resistance desperately needed and one of the most challenging goal in human health-care. In this context, the General Objective of SUPREME has been to fight multidrug resistant bacteria creating innovation in the implementation of novel therapeutic approaches based on the controlled delivery “unconventional” antibacterial species. This challenge has been addressed by fabrication of unprecedented supramolecular platforms based on branched polymeric cyclodextrins (PCDs) integrating visible light-activatable nitric oxide (NO) photodonors (NOPDs) alone or in combination with antibiotics currently employed. Towards this purpose, new devised PCDs have been used as suitable building blocks for the achievement of supramolecular nanogel and nanoparticle constructs integrating visible light activatable NOPDs. In addition, molecular hybrids integrating NOPD and conventional antibiotics are aimed to be fabricated. This global approach has aimed at circumventing the resistance machinery in MDR bacteria maximising the therapeutic efficacy and at limiting side effects typical for antibiotic drugs.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

With more than 13 million people dying per year from infectious diseases Multidrug Resistance (MDR) in bacteria remains thegreatest challenge in public health care. This scenario, associated to the low turnover of new clinically approved antibioticdrugs makes the development of innovative therapeutic approaches to fight antibiotic resistance desperately needed toaddress this devastating societal problem. In this frame, SUPREME aims at the implementation of a novel strategy basedon unprecedented supramolecular platforms based on new cyclodextrin polymers integrating light-activatable nitric oxide (NO)photodonors (NOPD), alone and in combination with antibiotics currently employed in the clinic. The final goal is to exploitthe double role of NO generated with superb spatiotemporal control thanks to the light triggering, as: i)bactericidal species not suffering MDR when produced at high doses (micro molar); ii) inhibitor of the efflux pumps mainly responsiblefor MDR, when produced at low doses, to revert antibiotic resistance. Highly biocompatible branched polymers containing mixed (alpha, beta and gamma) cyclodextrin units will be used as suitable hosts able to self-assemble into nanoparticles or gelsencapsulating the therapeutic cargo with high efficiency. We will focus on NOPDs activatable exclusively with thebiocompatible visible light and on antibiotics representative of the classes of fluoroquinolones andtetracyclines, known to display resistance and severe side effects. Full chemico-physical and photochemical characterizationof the systems is planned as well as assessment of their efficacy against planktonic microbial cells and biofilms. The complementaryexpertise of the researcher and the supervisor supported by the private and academic teams hosting the fellow duringsecondments will create a multidisciplinary environment where all participants will benefit from reciprocal transfer ofknowledge.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITA DEGLI STUDI DI CATANIA · CataniaКоординаторИталия
CYCLOLAB CIKLODEXTRIN KUTATO-FEJLESZTO KFT · BudapestУнгария
UNIVERSITA DEGLI STUDI DI MESSINA · MessinaИталия