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HEДокторантска мрежа2023–2026

GlycoNoVi · Understanding the Role of Glycans in Human Norovirus Infection: a Key to Unlock New Therapies

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2023-01-01 → 2026-12-31
Финансиране от ЕС
2 412 295 €
Участници
15
Схема
HORIZON-TMA-MSCA-DN

Линиите свързват координатора с партньорите.

Накратко на български

Гликаните (сложни захари) и тяхната роля при заразването на човека с норовирус се анализират чрез химия и вирусология. Това помага за разработването на нови методи за диагностика и противовирусни терапии срещу стомашно-чревните инфекции.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Understanding the Role of Glycans in Human Norovirus Infection: a Key to Unlock New Therapies

Norovirus infections are a major global health concern, causing acute gastroenteritis outbreaks with significant socio-economic impact. The GlycoNoVi project aims to unravel the role of glycans in norovirus infections, paving the way for novel antiviral strategies. By combining synthetic chemistry, structural biology, and virology, the project seeks to develop glycan-based therapeutics and diagnostics, ultimately reducing the burden of norovirus-related diseases worldwide.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Glycans are carbohydrate structures ubiquitously found on the surface of cells and take part in many biological processes, including cell signaling and neoplasia. Research on glycans is challenging in part due to the limited availability of biologically relevant synthetic glycans and to technical challenges in the analysis of glycan-protein interactions. Glycans also exhibit key roles in viral infections, mediating virus attachment and entry. Human noroviruses (NoVs) are the major cause of viral gastroenteritis and foodborne illnesses causing morbidity, mortality and economic losses. NoV infections are self-limiting in healthy individuals but are associated with severe complications in immunocompromised individuals, the elderly and young children. In addition, frequently occurring new NoV genotypes and variants can cause large outbreaks and epidemics worldwide. Very little is known about NoV infections in most non-human hosts and the close genetic similarities between some animal and human NoVs leads to the realistic hypothesis that the virus might jump the species barrier triggering pandemic variants. Importantly, no therapy is currently available to treat or prevent NoV infections. The requirement for NoVs to attach to specific glycans to infect hosts’ tissues, and cells, has been well established but the underlying mechanisms remain to be elucidated. Going beyond the state-of-the-art, the overall aims of GlycoNoVi is training 9 researchers to address knowledge gaps on NoV glycan interactions and investigate the exciting possibility of developing synthetic glycans as antiviral strategies to treat NoV infection. These aims will be achieved bringing together 5 academic and 3 industrial leaders in glycoscience, glycovirology and NoV field and relying on a multidisciplinary and interconnected approach which is declinate in research-oriented WP1-5 and WP6-8 focused respectively on training, outreach and coordination.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз