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HEДокторантска мрежа2023–2026

ReWire · Technology-driven combinatorial therapy to rewire the spinal cord after injury

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2023-01-01 → 2026-12-31
Финансиране от ЕС
2 666 837 €
Участници
26
Схема
HORIZON-TMA-MSCA-DN

Линиите свързват координатора с партньорите.

Накратко на български

Комбинирани терапии, включващи биоматериали, роботика и електрическа стимулация, се изследват за възстановяване на нервните връзки в гръбначния стълб. Това е важно, за да се подобрят двигателните и сетивните функции на хората след тежки наранявания и да се повиши качеството им на живот.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Technology-driven combinatorial therapy to rewire the spinal cord after injury

Traumatic spinal cord injuries (SCI) are primarily caused by mechanical damage to the central nervous system, with road traffic accidents and falls as main causes. They result in impairment of motor, sensory, and autonomic functions, thus requiring tailored and personalised treatment strategies. Plasticity can result in new connections and neural circuits, contributing to a compensatory recovery of function. There is substantial progress in understanding the cascade of cellular and molecular events, but there are still no effective interventions that mitigate the extent of damage, and current treatment strategies have proven insufficiently effective in patients. Conventional therapies focus on resolving individual aspects of SCI, thereby neglecting synergies to tackle multiple targets simultaneously. Technological advances in drug delivery systems, biomaterials, electronics, and robotics have resulted in novel developments to regain lost function after SCI. ReWIRE is evolving and combining these technological advances. The overall goal is to translate combinatorial SCI therapies from bench to bedside in a timely manner, thereby improving the quality of life and reducing societal burden. In ReWIRE, the Doctoral Candidates are exposed to basic SCI science and repair strategies, as well as cutting-edge technologies in related scientific fields. A special focus is set on personalised therapies, including tailored rehabilitation programs. To achieve this, ReWIRE is merging the following three key developments: i) reactivation, stimulation, and attraction of nerve growth using drug delivery systems ii) support and guidance of nerve growth with biomaterial bridges iii) enhancement and stabilization of nerve growth by inducing plasticity via electrical stimulation, robotics, and rehabilitation ReWIRE is set up to equip next-generation scientists with unique skills to develop ground-breaking therapeutic solutions for patients with SCI. ReWIRE’s first objective is to establish an international, interdisciplinary, and intersectoral educational network that develops and links high-tech routes into new personalized, combinatorial approaches to rewire the spinal cord. The second objective is to build a clinical data platform for SCI. The third objective is to position Europe at the forefront of therapy for SCI. The training and research parts are focused on developing the next generation specialists and technologies in the European Research Area. Specifically, ReWIRE aims to establish meaningful functional recovery by combining axonal regrowth and reconnection with new neuronal circuits, controlled by the brain and boosted by neuromodulation. The overall goal is to translate combinatorial SCI therapies from bench to bedside in a timely manner, thereby improving the quality of life and reducing societal burden. The convergent approach will lead to combinatorial therapies to repair the spinal cord after injury, which, to date, has not been successful using individual therapies.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

ReWIRE will combine innovative translational neurotechnologies and rehabilitation interventions for the repair and restoration of neurological functions following injury of the spinal cord (SC). The proposed research program will equip next-generation scientists with unique skills to develop disruptive therapeutic solutions for patients with paralysis. Recent technological breakthroughs have triggered a paradigm shift in the conception of therapies aimed to restore function after spinal cord injury (SCI). Novel drug delivery systems and biomaterial bridges have been engineered to reduce secondary injury and scarring, to stimulate and guide regenerating nerve fibres across the lesion site, and to promote functional reconnection with intact tissue. Additionally, neuromodulation therapies can reactivate spinal circuits below a SCI, allowing people with chronic paralysis to regain voluntary control of walking. In conjunction with rehabilitation, neurological recovery was promoted that persisted without neuromodulation, suggesting a rewiring of the SC as demonstrated in preclinical models. To bypass an injury, neuromodulation has been linked to brain signals to re-establish cortical control over spinal circuits by employing electrical nerve stimulation and robotic systems. Advances in robotics are significantly augmenting the impact of neurorehabilitation by inducing new natural “wired” connections. The aim of ReWIRE is to leverage all these technical and therapeutic breakthroughs in the framework of multiple PhD projects that will continuously interact to converge toward effective combinatorial treatments for SCI. ReWIRE will focus on three inter-woven objectives: i) establish an international, interdisciplinary, and intersectoral educational network, ii) build an SCI clinical data platform, and, iii) position Europe at the forefront of therapy for SCI.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз