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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
HEОбмен на изследователи2023–2026

AlgaeNet4AV · Training network for exploring microalgae diversity for the development of novel antiviral compounds

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2023-01-01 → 2026-12-31
Финансиране от ЕС
772 800 €
Участници
14
Схема
HORIZON-TMA-MSCA-SE

Линиите свързват координатора с партньорите.

Накратко на български

Микроводораслите се изследват за откриване на вещества като лектини и полифеноли, които могат да блокират прикрепянето на вируси към клетките. Това е важно за разработването на нови противовирусни средства, които действат по-бързо от съществуващите лекарства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Training network for exploring microalgae diversity for the development of novel antiviral compounds

Microalgae are very diverse, and adapted to a broad variety of environmental conditions, the chances to find novel and unexplored bioactive metabolites with properties of interest for biotechnological and biomedical applications are high. The potential of exploiting the microalgae-based ingredients with antiviral properties has already been documented (Falaise et al., 2016; Carbone et al 2021; Romero et al., 2021), however, due to the lack of systematic R&D efforts, these compounds are unexploited. Lectins and polyphenols from microalgae are compounds that display strong antiviral activities, that haven’t been exploited so far. Lectins are ubiquitous proteins/glycoproteins of non-immune origin that bind reversibly to carbohydrates in a non-covalent and highly specific manner. These lectin-glycan interactions could be exploited for the establishment of novel therapeutics, targeting the adherence stage of viruses and thus helpful in eliminating widespread viral infections (Singh et al., 2018; Lee et al., 2019; Car-bone et al 2021; Romero et al., 2021). They have a unique and rapid mode-of-action holding several advantages compared to conventional drugs. For ex-ample, their ability to bind viral surface sugars in seconds, makes them much faster than the existing drugs. Lectins resistance has not been observed among virus from diverse sources and resistant strains can generally not be selected during in vitro experiments. As we are still unable to predict with confidence the progress of the coronavirus pandemic and considering that the next pandemic is most likely to be caused by influenza, the discovery of antiviral compounds continues to be the priority public health threat in the world (Mani et al., 2020; Martinez et al., 2020). Most importantly, we need to have a range of available antiviral tools that can respond rapidly and effectively to emergencies. For practical application, non-drug antiviral compounds must be available in massive amounts and produced cost-effectively. These requirements might eliminate recombinant proteins from consideration as the time and costs of production in cell-based fermentation systems are prohibitively high. The main objective of the AlgaeNet4AV project is the characterization, and exploitation of microalgae biodiversity as a source for bio-based cosmetics with antiviral potential towards influenza and coronavirus pandemic strains. These products aims to be used as non-drug interventions for eliminating the propagation of harmful viruses and directly contribute to reduce the risk and speed of transmission, acting as first-line weapons towards pan-demic outbreaks.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The AlgaeNet4AV project seeks to exploit the microalgae biodiversity, as a source for high-added-value lectins and polyphenols with antiviral properties against influenza and coronavirus pandemic strains. Microalgae derived-compounds are easily amendable, bio-degradable, non-toxic and safe; thus, they are preferred to be used for the development of novel bio-based materials and cosmetics with antiviral potential. Lectins and polyphenols could be highly demanded non-drug interventions across the materials and cosmetics industry as a solution to reduce the risk and speed of contamination and transmission during pandemic outbreaks. The project will combine the whole value chain in order to: a) develop transcriptomics and metabolomics resources from microalgae diversity as a valuable source for the discovery novel lectins and polyphenols; b) characterize their spectrum of bioactivity and toxicity and provide structure-function relationships; c) develop and optimize application-based microalgae culture systems and downstream processing strategies for higher production rate of the desired compounds; d) develop, formulate and evaluate lectins and polyphenols-based final cosmetics products. The work will be supported by market assessment, integral biorefinery designs, techno-economic and sustainability assessment. Integrated value chains will be demonstrated to deliver proof-of-concept and demonstrate economic feasibility. AlgaeNet4AV is an industry-academia R&D and innovation project with a multidisciplinary approach aimed at generating robust business cases through technology development. The consortium composed by 11 partners, with 7 European and 2 third-country (USA & Japan) prominent research organisations. Strong industrial leadership is guaranteed through the participation of 5 SMEs. The projects goals will be achieved through a sustainable way helping meet the increasing demand while creating a positive environmental impact through reduction of carbon emissions.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз