HEИндивидуална стипендия2022–2025

VibroZyme · Mechanoredox-Biocatalysis: Functional enzyme supports that harvest vibrational energy to power redox biocatalysis

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2022-11-01 → 2025-07-31
Финансиране от ЕС: 230 774 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Нови полимерни материали превръщат механичната енергия от вибрации или ултразвук в енергия за работата на ензими. Това може да направи индустриалните биопроцеси по-евтини и екологични, като намали нуждата от скъпи химикали и сложни източници на захранване.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Mechanoredox-Biocatalysis: Functional enzyme supports that harvest vibrational energy to power redox biocatalysis

The VibroZyme project set out to tackle one of the grand challenges in sustainable biotechnology: how to power industrial enzymes in a simple, clean, and cost-effective way. Many valuable biocatalysts depend on costly cofactors or complex external energy inputs, which limits their large-scale use in areas such as green chemistry and CO2 conversion. VibroZyme’s vision was to use everyday mechanical energy—such as vibrations from pumps or ultrasound—to directly drive enzyme reactions. The overall objective was to create new piezo-polymer composite materials that can harvest mechanical energy and convert it into the redox equivalents that enzymes require. By developing these functional supports and integrating them with model enzymes, the project aimed to open an entirely new pathway for industrial biocatalysis. This aligns strongly with European strategic priorities, including the European Green Deal, by supporting greener manufacturing and more sustainable use of natural resources. If successful at scale, this approach could lower costs, simplify processes, and enable new applications of biotechnology in energy, materials, and environmental protection.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Redox enzymes are a diverse enzyme class with significant industrial potential, improving sustainability in food, fuel and CO2 conversion. However, redox enzymes need a source of energy (electrons) to power their important reactions. While nature employs electrons transferred from cofactors (e.g. NAD(P)H) to drive redox biocatalysis, industry translation requires the addition of sacrificial chemicals, which increases cost, waste, and purification, and impedes scalability. This project aims to develop a new method to power redox enzymes using mechanical energy and piezoelectric materials, establishing a unique research field in mechanoredox biocatalysis. Inspired by natural mechanotransduction, where living systems convert mechanical stimuli into electrochemical activity, I will employ mechanoredox materials to transform ubiquitous vibrational energy from the environment into a sustainable supply of electrons to power redox biocatalysis. I will demonstrate this technology by coupling scalable piezoelectric-polymer composites with formate dehydrogenase (FDH) as a model enzyme, for vibration-powered CO2 reduction. First, I will design, construct and optimise piezo-polymer beads and films that generate a mechanoredox potential matched to redox enzymes. Next, I will couple these materials with FDH to catalyse CO2 reduction using vibrations from pumping as mechanical stimulus. Two routes will be explored, namely mediated and direct energy transfer (MET and DET) from the stimulated mechanoredox materials, culminating in a platform technology for exploiting redox enzymes in industry. I will gain extensive scientific and transferable skills from the team of Prof. Anne Meyer at DTU and my industry partner Novozymes to support my career development, including enzyme production and immobilization, and commercialisation. VibroZyme embodies a new strategy to enhance the scalability, sustainability and productivity of redox biomanufacturing, with immense commercial potential.

Оригинален текст от CORDIS (на английски).

Участници

DANMARKS TEKNISKE UNIVERSITET · Kongens LyngbyКоординаторДания