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HEОбмен на изследователи2023–2026

MET-EFFECT · Metal complexes of a naturally inspired framework functionalized for cytotoxic and catalytic efficiency

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2023-01-01 → 2026-12-31
Финансиране от ЕС
763 600 €
Участници
6
Схема
HORIZON-TMA-MSCA-SE

Линиите свързват координатора с партньорите.

Накратко на български

Метални комплекси, създадени от природния флавоноид апигенин и елементи като рений и иридий, се тестват за действие срещу ракови клетки. Те помагат за разработването на по-ефективни лекарства и устойчиви катализатори за химични реакции във водна среда.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Metal complexes of a naturally inspired framework functionalized for cytotoxic andcatalytic efficiency

MET-EFFECT explores bioinspired metal complexes by integrating a natural flavonoid scaffold, apigenin (apg), with high-valent metal centers (Re(V) and Ir(III)), developing multifunctional compounds for medicine and catalysis. This work advances anticancer drug development and sustainable catalysis by highlighting renewable resources and fine-tuning molecular properties. In the center of our approach is apg, a functional, naturally occurring flavonoid, known for its strong anticancer activity. We derivatized it and coordinated with high-valent metal centers, creating a molecule with tunable physicochemical properties. The synthesis of novel compounds involved an optimized strategy, yielding fully characterized ligand precursors and new Re(V) complexes. Our methodology has set up a base for the future development of Ir(III)-based systems, which are expected to provide complementary functionalities. The solubility of these complexes in water enhances their biological applicability and enables catalytic reactions in sustainable, aqueous conditions. The cytotoxicity of Re(V) and Ir(III) complexes was tested across a range of cancer cell lines. Re(V)-apg complexes demonstrated increased cytotoxicity compared to the free ligand, with a promising lead compound showing activity against T-cell leukemia. These results provide insights into structure-activity relationships (SAR) and guide modifications for improved efficacy. Beyond biomedical applications, the Re-based catalysts demonstrated catalytic activity in olefin epoxidation, offering a sustainable alternative to organic solvents. Upcoming research will explore water oxidation catalysis, crucial for artificial photosynthesis and sustainable energy conversion, with a focus on Ir(III) complexes to enable efficient oxidation. MET-EFFECT mission moves toward a sustainable future by reducing environmental impact and generating recycling protocols for common organic solvents. The next phase will address metal recycling, as recovering and reusing precious metals is a key challenge. The R&I results emerged from 33 secondments (79 project months) and involved 20 researchers across 5 countries. These collaborations advanced career prospects, fostered teamwork, and expanded research perspectives. The team actively participated in conferences, workshops, and other outreach activities. Dissemination continues through the MET-EFFECT website, LinkedIn, and Instagram.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The immense power of practice-oriented synthetic chemistry is demonstrated through the opportunity to design, synthesize, optimize, produce and apply a molecule of a desirable structure for a given purpose. In the light of its ability to bridge chemical structure with a function, MET-EFFECT proposes brand new concept of novel multifunctional rhenium and iridium flavonoid complexes aimed to serve as metallodrugs and homogenous catalysts. The fusion of academic knowledge and industry-oriented perspective establishes a fruitful collaboration of an international and intersectoral profile. Well-recognized members of Consortium gains beyond the-state-of-the-art advances in bioinorganic chemistry by: a) developing novel Re and Ir complexes containing apigenin-like ligands, a natural bioactive flavone-type of molecules; b) determining the antitumor potential of newly synthesized Re(V) and Ir(III) complexes on a panel of various human cancer cell lines; c) evaluating the applicative potential of novel Re(V) complexes as homogeneous catalysts in OAT-inspired reactions (olefin epoxidation, oxoanions catalytic reduction and water oxidation). The structure and sentence of 7 work packages implemented through 37 secondments will enable the promotion of newly synthesized metal-based compounds in industrial environment for the sake of reaching their final applications. The widespread partnership creates an outstanding, R&I oriented ambient ensuring free knowledge sharing and career upgrade of the participating staff. By developing functional metal-based molecules, MET-EFFECT encompasses full human intellectual capacity capable to challenge technical, economic and environmental demands of wider society for applied but sustainable chemistry.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз