HEИндивидуална стипендия2024–2026

VThrombectomy · Improving Treatment of Ischemic Stroke Using Virtual Thrombectomy

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2024-01-16 → 2026-01-15
Финансиране от ЕС: 188 590 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Виртуалната тромбектомия изследва как фактори като състава на съсирека и гъвкавостта на кръвоносните съдове влияят върху отстраняването на запушване в мозъка. Това помага за подобряване на дизайна на медицинските устройства и оптимизиране на процедурата при исхемичен инсулт.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Improving Treatment of Ischemic Stroke Using Virtual Thrombectomy

Acute ischemic stroke is a major cause of mortality and long-term disability worldwide. Mechanical thrombectomy has significantly improved patient outcomes; however, its success remains highly variable, particularly in tortuous cerebral anatomies and for clots with differing mechanical properties. Current clinical practice lacks quantitative tools to predict thrombectomy performance and relies largely on physician experience. The objective of the VThrombectomy project was to develop and validate a virtual thrombectomy framework that integrates advanced computational modeling with in vitro experimentation. The project aimed to identify and quantify the biomechanical factors—such as clot composition, frictional interactions, vessel flexibility, and device mechanics—that govern thrombectomy success and failure. By doing so, the project sought to provide mechanistic insights that can support device design, procedural optimization, and future in silico clinical trials.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Acute Ischemic Stroke (AIS) is the leading cause of death and disability globally. In 2017, 1.12 million people suffered from a stroke in European Union, and it is expected to increase by 27% in 2047. The AIS occurred due to insufficient blood supply to the brain from blockage of blood clots or thrombus. Restoration of the blood supply to the brain is the primary objective of medical treatment after the detection of AIS. This can be done using recently developed minimally invasive Endovascular Stroke Treatment (EVT). The introduction of EVT to clinical trials in 2012 revolutionised stroke treatment, but nearly 65% of patients face post-treatment complications and disabilities. Such complications show a huge void in improving the EVT treatment using in silico and in vitro approaches.The current project (VThrombectomy) proposes a framework for mimicking the EVT procedure using in silico approach. The EVT consists of three major components: stent retriever, blood clot, and flexible blood vessel. Mimicking these components for numerical simulations and understanding the mechanical forces involved is the primary objective of this project. In which, Patient-based images will be used to mimic the cerebral arterial network, and mechanical properties of thrombus will be replicated using patient-based clot stress-strain data. The development of a virtual thrombectomy procedure will take place by solving these components using a multiphysics approach in a coupled way. The major limitations involved in the previous studies were the use of an ideal cerebral artery model with rigid walls and the absence of blood flow during EVT. VThrombectomy proposes to address these limitations by the inclusion of patient-specific flexible blood vessels with flowing blood. Parametric analysis of EVT using in silico approach can dive deep into the treatment and improves our understanding of the mechanical forces involved, which results in improved and efficient devices to retrieve the clot.

Оригинален текст от CORDIS (на английски).

Участници

POLITECNICO DI MILANO · MilanoКоординаторИталия