HEИндивидуална стипендия2023–2025

HyperK · Differential effects of dietary potassium intake on blood pressure

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-10-01 → 2025-09-30
Финансиране от ЕС: 214 934 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Влиянието на калиевия прием върху кръвното налягане се анализира чрез механизмите в бъбреците и съдовете. Разбирането на тези процеси помага за по-доброто дългосрочно управление на хипертонията и намаляване на сърдечно-съдовите рискове.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Differential effects of dietary potassium intake on blood pressure

As the main risk factor for the onset of cardiovascular disease, hypertension is a major contributor to premature death and disability. High salt in the diet is often considered a primary culprit for hypertension, but growing evidence indicates that increasing potassium in the diet may lower blood pressure (BP). However, dietary, observational or potassium intervention studies in animals or humans indicate that higher potassium intake is not always beneficial for BP. Reducing and maintaining a lower BP based on dietary intervention requires understanding of the long term and/or accumulated effects of the intervention and the underlying molecular basis. This project aims to increase our understanding of these different effects of dietary potassium on BP by examining the regulation mechanisms at play in the kidney. The main objectives are to: 1) Determine the optimum dietary potassium intake that reduces and sustains a lower BP; 2) Identify factors in the kidney that drive potassium sensitivity of BP; 3) Assess if sustained high dietary potassium intake changes vascular function; 4) Investigate the molecular basis of any vascular remodeling that promotes, or is consequential, to increased BP during prolonged high dietary potassium intake. Current pharmaceutical approaches for the management of high BP are quite effective, but adequate long-term management or responses are difficult to achieve: cardiovascular risk is nearly double in treated hypertension subjects than in individuals with normal blood pressure. This observation makes it necessary to study basic physiological questions to provide new insights into BP control. A major outcome of this research is to define if BP can be reduced long-term by manipulating dietary potassium intake. While specific drugs (that antagonize the renin-angiotensin aldosterone system) have transformed cardiovascular care, their usefulness is often limited by hyperkalemia (high potassium in the blood), which carries a significantly increased risk of mortality. New drugs to address this limitation act indirectly and have not proven popular. My studies may identify new targets in the kidney or vasculature that could be pharmaceutically exploited to manipulate BP without these limitations.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

As the primary risk factor for the onset of cardiovascular disease, hypertension is a major contributor to premature death and disability. High dietary sodium (Na+) consumption is often considered a primary culprit for hypertension, but evidence exists that increasing dietary potassium (K+) consumption may lower blood pressure (BP). However, a number of studies in humans indicate that higher K+ intake is not always beneficial for blood pressure effects that the host lab recently confirmed in rodents. Reducing and maintaining a lower BP based on dietary intervention requires understanding of the long term and/or accumulated effects of the intervention and the underlying molecular basis. This project will increase our understanding of the differential effects of dietary K+ on BP, the role of the kidney and potentially the vasculature. The project objectives are to: 1) determine the optimum dietary K+ intake that reduces and sustains lower BP; 2) identify factors in the kidney that drive K+ sensitivity of BP; 3) assess if sustained high dietary K+ intake changes vascular function; 4) investigate the molecular basis of any vascular remodelling that promotes, or is consequential, to increased BP during prolonged high dietary K+ intake. To address these questions I will apply a broad range of interdisciplinary skills and methods: telemetric monitoring of BP, in vivo assessment of kidney and vascular function in animal models and gene modified mice, RNA sequencing (including single-cell) and bioinformatics, optical clearing and innovative 3D multiplex imaging of tissues. Successful completion of the research in this proposal provides an excellent opportunity to uncover new targets and strategies for the management of hypertension. From a personal perspective it represents a major step towards establishing myself as an independent researcher in the area of renal-vascular crosstalk.

Оригинален текст от CORDIS (на английски).

Участници

AARHUS UNIVERSITET · Aarhus CКоординаторДания