HEИндивидуална стипендия2024–2026

UroAPROD · The gut and bias benefits - the investigation on urolithin metabotypes. Producer strains isolation and multiomic-based description of ellagitannin biotransformation.

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2024-02-01 → 2026-02-28
Финансиране от ЕС: 191 760 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Микробите в червата превръщат полифенолите от храни като орехи и нарове в полезни метаболити, наречени уролитини. Разбирането на този процес помага за създаването на персонализирано хранене и оценка на влиянието на антимикробните средства върху здравето.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

The gut and bias benefits - the investigation on urolithin metabotypes. Producer strains isolation and multiomic-based description of ellagitannin biotransformation.

The human gut microbiome plays a crucial role in transforming dietary compounds into bioactive metabolites that can influence health. One important example is the conversion of ellagitannins—polyphenols found in foods such as pomegranates and walnuts—into urolithins, a class of metabolites associated with beneficial effects on metabolism, inflammation, and muscle function. However, not all individuals have urolithins produced, and the underlying microbial mechanisms remain poorly understood. This project aimed to better understand how gut microorganisms transform dietary polyphenols and why individuals differ in their capacity to produce bioactive metabolites. A key objective was to identify microbial processes and factors influencing urolithin production, including the role of external perturbations such as antimicrobial agents. The project also sought to develop and apply advanced analytical and data-driven approaches to link microbial composition with metabolic outputs. The work addresses important societal and scientific challenges aligned with European priorities in health, nutrition, and microbiome research. By improving our understanding of diet–microbiome interactions, the project contributes to the development of personalised nutrition strategies and supports innovation in functional foods and preventive healthcare. It also provides knowledge relevant for assessing unintended effects of antimicrobial exposure on beneficial microbial functions.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Ellagitannin-rich herbal remedies are used traditionally because of their anti-inflammatory activity. This is connected not to ellagitannins themselves but to their metabolites produced by the gut microbiota. Urolithin A (UroA) is recognized as the most significant of all ellagitannins’ metabolites. However, not everyone is able to have it produced in their gut. The UroA production is exclusive to the hosts of urolithin metabotype A (UM-A) and B (UM-B) and is most probably dependent on the gut microbiota composition and activity. Preliminary trials showed that UM-A hosts have a lower risk of cardiovascular disease. Moreover, the transition from UM-A to other metabotypes is also connected to aging, which might suggest losing certain beneficial abilities. The identity of microorganisms that differentiate UroA producers were not yet revealed. If recognized, new probiotics might be designed. Providing non-UM-A hosts with the possibility to produce UroA efficiently would grant them an advantage due to reports of a wide range of proven and indicated UroAs biological activities.The project aims to isolate, characterize and preserve bacterial strains able to produce UroA from the fecal samples of UM-A and UM-B donors. This will be possible due to innovative substrate conversion screening strategies and novel metabolomic and sequencing techniques utilization. Results will provide missing insights about urolithin metabotypes for further explanatory studies focused on the elucidation of UM-dependant features. Moreover, bioinformatic tools will be developed to obtain multi-omic descriptions of the studied processes, combining metabolomic and targeted metagenomic data. The project will deliver protocols and data analysis methods that will enable us to run advanced projects in the field of natural products biotransformation research. The established pipelines will be suitable also for dysbiosis, xenobiotic-microbiome interaction and pre- and probiotic design studies.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITEIT ANTWERPEN · AntwerpenКоординаторБелгия