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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
HEИндивидуална стипендия2023–2027

Wide-Band Ephys · Large-scale and wide-band brain dynamics mediating memory consolidation in the freely moving rat

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2023-09-01 → 2027-01-31
Финансиране от ЕС
307 785 €
Участници
5
Схема
HORIZON-TMA-MSCA-PF-GF

Линиите свързват координатора с партньорите.

Накратко на български

Връзката между бавните и бързите мозъчни вълни при плъхове се проучва, за да се разбере как хипокампусът и кората съхраняват спомените. Това помага за по-доброто разбиране на механизмите при деменцията и разработването на по-малко инвазивни интерфейси за медицината.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Large-scale and wide-band brain dynamics mediating memory consolidation in the freely moving rat

Dementia is a major healthcare challenge worldwide due to its high incidence and its strong impact on the life quality of patients and on society as a whole. Development of treatments for the mitigation of memory impairment in patients with dementia has proven very challenging, partly due to our limited understanding of the underlying mechanisms of memory consolidation. Memory consolidation is mediated by communication between large-scale networks in the brain, particularly the hippocampal formation and cortical circuits, coordinated by oscillations in neuronal activity. In humans, this coordination is associated with complex resting-state network (RSN) dynamics that are reflected in infra-slow (<0.5Hz) brain activity across the entire brain that can be measured using bulky fMRI systems. However, the link between RSNs dynamics and well-understood fast neuronal dynamics underlying memory consolidation in animal models remains a major knowledge gap due to technical limitations. Wide-Band Ephys is addressing this gap by mapping extracellular potentials with high spatial and temporal resolution from extremely slow fluctuations to fast neuronal dynamics. Using customized graphene-based neural probes in combination with high density intracortical probes and closed-loop neuromodulation, I aim to investigate the topographical coupling between the neuronal activity in various cortical regions and in the hippocampus during the process of memory consolidation and understanding how infra-slow network dynamics shape this communication. Furthermore, the project is exploring novel concepts for neural interfaces that minimize the invasiveness of large-scale brain mapping in order to maximize its potential for clinical applications.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Dementia is a major healthcare challenge worldwide due to its high incidence and its strong impact on the life quality of patients and on society as a whole. Development of treatments for the mitigation of memory impairment in patients with dementia has proven very challenging, partly due to our limited understanding of the underlying mechanisms of memory consolidation. Memory consolidation is mediated by communication between large-scale networks in the brain, particularly the hippocampal formation and neocortical circuits, coordinated by synchronous oscillatory dynamics, as shown in both humans and animal models during the resting state. In humans, this coordination is associated with complex resting-state network (RSN) dynamics that are reflected in spatio-temporal patterns of infra-slow (<0.5Hz) brain activity. However, the link between RSNs dynamics and well-understood neuronal dynamics underlying memory consolidation in animal models remains a major knowledge gap due to technical limitations. Wide-Band Ephys has a unique potential to close this gap by mapping extracellular potentials with high spatio-temporal resolution in a wide frequency band, enabling inference of RSN dynamics across brain-wide networks in freely moving rats. Using customized graphene-based neural probes in combination with Neuropixel 2.0 probes, fiber-photometry and optogenetics, I aim to investigate the mechanisms underlying memory consolidation with an unprecedented level of detail. Extending the current knowledge on the functional role of RSNs and local slow oscillations in the rat could lead to the development of novel treatments for dementia, which will be explored in collaboration with the private sector during this project. The interdisciplinary approach presented in this proposal will complement my expertise in neurotechnology with more advanced skills in fundamental neuroscience, enhancing my career prospects in the field of translational neuroscience.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз